Disperse and acid azo dyes having one or two cinnamoyl substituents on a thiazole, isothiazole or thiadiazole diazonium moiety and having an aniline, tetrahydroquinoline or benzomorpholine coupler

ABSTRACT

Disclosed are azo dyes containing diazonium moieties from aminothiazoles, aminoisothiazoles, or aminothiadiazoles (1,2,4- or 1,3,4-), and certain coupler moieties from aniline, tetrahydroquinoline, and benzomorpholine type compounds, wherein the diazonium moieties have at least one cinnamoyl group, and wherein a wide variety of groups, e.g., one or more water-solubilizing substituents such as sulfonic acid groups or their metal or amine salts may be present in the dye molecule. These dyes are useful for dyeing materials selected from polyamide, cellulose ester, polyester, wool and other natural and synthetic fibers and generally exhibit improvements in dyeability and fastness properties.

This invention relates to azo dyes containing diazonium moieties from aminothiazoles, aminoisothiazoles, or aminothiadiazoles (1,2,4- or 1,3,4-), and certain coupler moieties from aniline, tetrahydroquinoline, and benzomorpholine type compounds, wherein the diazonium moieties have at least one cinnamoyl group, and wherein a wide variety of groups, e.g., one or more water-solubilizing substituents such as sulfonic acid groups or their metal or amine salts may be present in the dye molecule. These dyes are useful for dyeing materials selected from polyamide, cellulose ester, polyester, wool and other natural and synthetic fibers and generally exhibit improvements in dyeability and fastness properties.

The present dyes have the general structures ##STR1## wherein: each A is a group of the structure ##STR2## C¹ is an aniline, tetrahydroquinoline, or benzomorpholine type coupler which may be substituted; ring E is unsubstituted or substituted in any position not occupied by a cinnamoyl group, with a group preferably selected from alkyl, halogen, cyano, carbamoyl, CONHalkyl, alkoxycarbonyl, alkanoyl, alkanoyloxy, alkylthio, alkenylthio, arylthio cyclohexylthio, aryloxy, and alkoxy; ring G is unsubstituted or substituted in any position not occupied by a cinnamoyl group with a group preferably selected from alkyl, aryl, alkoxycarbonyl, alkanoyloxy, carbamoyl, CONHalkyl, CON(alky)₂, halogen, cyano, thiocyano, alkylthio, alkylsulfonyl, arylsulfonyl, formyl, acyl, and aroyl; R₅ is H or alkyl; and each R₁ is a group selected from alkyl, alkenyl of 2-6 carbons, aryl, cyclohexyl, alkoxy, halogen, hydroxy, alkylsulfonyl, cyano, carbamoyl, alkanoyl, alkanoyloxy, aroyl, alkoxycarbonyl, amino sulfamoyl, alkylsulfamoyl, dialkylsulfamoyl, alkanoylamino, SO₃ C₆ H₅, alkylthio, thiocyano, arylsulfonyl, formyl, alkylcarbamoyl, dialkylcarbamoyl, NO₂, --SO₃ M, --OSO₃ M, --COOH, aryloxy, arylthio, alkylsulfonylamino, aroylamino, arylsulfonylamino, and cyclohexylthio, wherein the alkyl, alkylene, alkenyl, aryl, and cyclohexyl moieties of the above R₁ groups, e.g., the alkyl portions of the alkanoyl groups, are unsubstituted or substituted with 1-3 substituents different from the parent moiety and independently selected from alkanoyloxy, alkyl, alkenyl, succinimido (C₄ H₄ O₂ N), --NO₂, alkanoylamino, alkylsulfonylamino, 1-(2-pyrrolidono) (C₄ H.sub. 6 ON), halogen, cyano, alkoxy, aryl, cyclohexyl, hydroxy, --SO₃ M, --OSO₃ M, aryloxy, furyl (C₄ H₃ O), aroyloxy, alkoxycarbonyl, --SO₂ N-- (alkyl)2, NHCOOalkyl, NHCONHalkyl, glutarimido (C₅ H₆ O₂ N), phthalimido (C₈ H₄ O₂ N), CONH₂, CONHalkyl, CON(alkyl)₂, alkoxyalkoxy, alkylthio, arylthio, alkylsulfonyl, and arylsulfonyl, wherein M is selected from H⁺, NH₄ ⁺, Na³⁰ , K⁺, and the colorless cations of salts of primary, secondary, and tertiary aliphatic and arylamines, such as triethylamine, tri(2-hydroxyethyl)amine, di(2-hydroxyethyl)amine, N,N-dimethylaniline, and especially trimethylamine.

The couplers C¹ preferably have the formulae: ##STR3## wherein each R₁ is defined above; R₂ and R₇ are each selected independently from hydrogen, alkyl, alkenyl of 2-6 carbons, aryl, and cyclohexyl, all of which groups are unsubstituted or substituted as defined above for the substituted R₁ groups; and R₃, R₄ and R₈ are each selected from hydrogen and alkyl.

The various alkyl and alkylene moieties of R₁, R₂, R₃, R₄, R₅, R₇ and R₈, including those contained, for example, in alkoxy, alkanoyl, and alkoxyalkoxy groups within the above definitions preferably contain up to 6 carbons, and they and the alkenyl groups may be straight or branched chain, and the above aryl groups preferably contain from 6-10 ring carbons.

The following are typical specific R₁ groups: CH₃, Cl, SO₂ C₂ H₅, CN, CONH₂, COC₂ H₅, COC₆ H₅, COOC₂ H₅, SO₂ NH₂, SO₂ NHCH₃, SO₂ N(C₂ H₅)₂, NHCOC₂ H₅, SO₃ C₆ H₅, SCH₃, SCN, SO₂ C₆ H₅, CHO, CONHC₂ H₅, CON(C₂ H₅)₂, OH, NO₂, C₆ H₅, C₆ H₁₁, SO₃ K, CF₃, CH₂ OOCC₂ H₅, Br, SO₂ CH₂ CH₂ OC₂ H₅, I, CONHCH₂ CN, COCH₂ CH₂ OH, COC₆ H₃ --o--CH₃ --p--OCH₃, COOC₂ H₄ --CH═CH₂, SO₂ NHCH₂ CH₂ CN, SO₂ NHCH₂ -succinimido, SO₂ NHC₂ H₄ --C₆ H₅, NHCOCH₂ CH₂ Cl, SO₃ C₆ H₄ --p--NO₂, SCH₂ CH₂ OH, SC₂ H₄ --C₆ H₁₁, SO₂ C₆ H₄ --p--NHCOCH₃, C₆ H₄ --p--NHSO₂ CH₃, CONHC₂ H₄ NHSO₂ CH₃, CONHCH₂ CH₂ OH, CH₂ CH₂ NO₂, C₆ H₄ --p--(2-pyrrolidono), C₆ H₁₀ --4--CN, OSO₃ K, CH₂ SO₃ Na, OC₆ H₅, SO₂ C₂ H₄ OSO₃ K, C₂ H₄ --furyl, C₂ H₄ OOCC₆ H₅, COCH₂ CH₂ COOCH₃, COC₆ H₄ --p--SO₂ NHC₆ H₅, COOCH₂ CH₂ SO₂ NHCH₃, SO₂ NHCH₂ SO₂ N(C₂ H₅)₂, SO₂ NHCH₂ NHCOOCH₃, SO₂ NHC₂ H₄ NHCONHCH₃, NHCOCH₂ CH₂ --glutarimido, SO₃ C₆ H₄ --p--phthalimido, SCH₂ CONH₂, C₆ H₄ --p--SO₂ CH₃, SO₂ C₆ H₄ --p--CONHCH₂ SO₃ Na, CH₂ SO₂ C₆ H₅, CONHCH₂ CH₂ CON(CH₃)₂, CONHCH₂ CH₂ OCH₂ CH₂ OCH₂ CH₃, CH₂ CH₂ SO₃ H, C₆ H₄ -- p--SC₂ H₅, NHCOCH₃, C₆ H₁₀ --4--SC₆ H₄ (p-OSO₃ H), CH₂ CH═CH₂, COOH, OC₆ H₅, OCH₃, SC₆ H₅, NHSO₂ CH₃, NHCOC₆ H₅, NH₂, NHSO₂ C₆ H₅, SC₆ H₁₁, and OOCCH₃.

Typical for R₃, R₄, R₅ and R₈ are: H, CH₃, C₂ H₅, C₄ H₉ --n, and CH₂ (CH₃)₂.

The following are typical specific R₂ and R₇ substituents: H, CH₃, C₂ H₅, C₄ H₉ --n, CH₂ CH═CH₂, C₆ H₅, C₆ H₁₁, CH₂ OOCC₂ H₅, CH₂ CH₂ OC₂ H₅, CH₂ CN, CH₂ CH₂ OH, C₆ H₃ --o--CH₃ --p--OCH₃, C₂ H₄ --CH═CH₂, CH₂ -succinimido, CH₂ CH₂ --C₆ H₅, CH₂ CH₂ Cl, C₆ H₄ --p--NO₂ CH₂ CH₂ --C₆ H₁₁, C₆ H₄ --p--NHSO₂ CH₃, C₂ H₄ NHSO₂ CH₃, CH₂ CH₂ NO₂, C₆ H₄ --p--(2-pyrrolidono), C₆ H₁₀ --4--CN, CH₂ SO₃ Na, CH₂ CH₂ OSO₃ K, CH₂ CH₂ --furyl, CH₂ CH₂ OOCC₆ H₅, CH.sub. 2 CH₂ COOCH₃, C₆ H₅ --p--SO₂ NHC₆ H₅, CH₂ CH₂ SO₂ NHCH₃, CH₂ SO₂ N(C₂ H₅)₂, CH₂ NHCOOCH₃, CH₂ CH₂ NHCONHCH₃, CH₂ CH₂ --glutarimido, C₆ H₄ --p--phthalimido, CH₂ CONH₂, C₆ H₄ --p--SO₂ CH₃, C₆ H₄ --p--CONHCH₂ SO₃ Na, CH₂ SO₂ C₆ H₅, CH₂ CH₂ CON(CH₃)₂, C₂ CH₂ OCH₂ CH₂ OC₂ H₅, CH₂ CH₂ SO₃ H, C₆ H₄ --p--SC₂ H₅, and C₆ H₁₀ --4--SC₆ H₄ (p--OSO₃ H).

Preferred substituents for the E and H rings in addition to hydrogen are alkyl, alkylthio, halogen, cyano, alkoxycarbonyl, alkanoyl and alkanoyloxy; for each R₁ on the cinnamoyl rings are H, alkyl, aralkyl, aralkyl substituted with --SO₃ M or --SO₄ M, cyclohexylalkyl, cyclohexylalkyl substituted with --SO₃ M or --SO₄ M, alkoxy, or alkanoylamino; for R₂ are H or alkyl, aralkyl, aralkyl substituted with --SO₃ M or --SO₄ M, cyclohexylalkyl, cyclohexylalkyl substituted with --SO₃ M or --SO₄ M; for R₇ are H, alkyl, aralkyl, aralkyl substituted with --SO₃ M or --SO₄ M, cyclohexylalkyl, cyclohexylalkyl substituted with --SO₃ M or --SO₄ M, sodio- or potassiosulfatoalkyl, sodio- or potassiosulfonicalkyl, or alkanoyloxyalkyl; for each R₁ on the couplers are H, aralkyl, aralkyl substituted with --SO₃ M or --SO₄ M, cyclohexylalkyl, cyclohexylalkyl substituted with --SO₃ M or --SO₄ M, --SO₃ Na, --SO₃ K, halogen, --SO₄ Na, --SO₄ K, alkyl, alkoxy, --COOH, or --OH; for R₃, R₄ and R₈ are H and alkyl; and for R.sub. 5 is hydrogen.

The dyes of this invention impart red to blue shades on natural and synthetic fibers and exhibit improvements over such dyes as disclosed in U.S. Pat. No. 2,805,218 and British Pat. No. 1,021,399 in one or more properties such as fastness to light, ozone, chlorine, oxides of nitrogen, washing, sublimation, heat disintegration, perspiration, and crocking, leveling, transfer, exhaustion, build, pH stability, and resistance to blooming.

The intermediate compounds used in this invention are prepared according to procedures well known to the art. The present dyes are readily prepared, for example, by reacting the acetyl group of the intermediate azo compound, which itself is a dye, with benzaldehyde or a substituted benzaldehyde in acetic acid with concentrated sulphuric acid as catalyst. The acetyl dye is thus converted to a cinnamoyl substituted dye in high yield. The water-solubilizing group may be the substituent on the benzaldehyde or it may be introduced into the cinnamoyl dye at a later stage by known methods. For example, a hydroxy group in either the diazonium component or the coupling component could be reacted with sulphuric acid and then with MOH to give the --OSO₃ M group. Alternatively, a chloroalkyl group in the dye could be reacted with K₂ SO₃ to give the --CH₂ SO₃ K group. Also, sulphonation of an aromatic ring or other reactive group in the dye with a sulphonating agent such as H₂ SO₄ or Cl--SO₂ H would give the solubilizing group. Such groups could also be present in the coupling component prior to diazotization and coupling.

The following Preparations, Example and tables illustrate the making and use of intermediates for the synthesis of dyes of the present invention.

PREPARATION A α-(N-Ethylanilino)-Toluenesulfonic Acid

To 30.0 g. of 100% sulfuric acid is added N-benzyl-N-ethylaniline (30.0 g.) dropwise below about 50° C. To this solution is added, at 50°-60° C., 60% oleum (30.0 g.) with good stirring. The mixture is stirred and heated at about 60° C. for three hours and then drowned into 200 ml of water. The free sulfonic acid (Coupler I) which is mostly the meta isomer with a small amount of para, precipitates on standing and is collected by filtration, washed with water, and dried. N-Benzylanilines containing groups such as alkyl, alkoxy, and halogen in the ortho, meta, or para positions of the benzyl group may also be sulfonated by this procedure. The exact location of the sulfonic acid group in these cases is often not known and mixtures usually are produced.

Aromatic amines which contain N-aralkyl groups and which are sulfonated by the above procedure to give Couplers 2 to 11 are listed below.

    ______________________________________                                         COUPLER NO. Sulfonation product of:                                            ______________________________________                                         2           N--Benzyl-N--ethyl-m-toluidine;                                    3           N--Benzyl-2,7-dimethyl-1,2,3,4-                                                tetrahydroquinoline;                                               4           N--Benzyl-2,3-dihydro-3,6-dimethyl-                                            1,4-benzoxazine;                                                   5           N--Methyl-N--(2-phenylethyl)aniline;                               6           N--Ethyl-N--(4-phenylbutyl)-3-                                                 chloroaniline;                                                     7           N,N--Dibenzylaniline;                                              8           N--Benzyl-2,5-dimethylaniline;                                     9           N--Benzyl-2-methoxy-5-methylaniline;                               10          N--Benzyl-2-methoxy-5-chloroaniline; and                           11          N--Benzyl-N--cyclohexylaniline.                                    ______________________________________                                    

PREPARATION B Diazotization and Coupling of 2-Amino-5-acetyl-1,3,4-thiadiazole

Sodium nitrite (3.6 g.) is added portionwise to 25 ml. of concentrated H₂ SO₄. The solution is cooled and 100 ml of 1:5 acid is added below 15° C. The mixture is cooled and 0.055 m. of 2-amino-5-acetyl-1,3,4-thiadiazole is added below 10° C. After stirring at 0°-5° C. for two hours, a 0.005 m. aliquot of the diazonium salt is added to a chilled solution of 0.005 m. of each of the Couplers 1-11 in 1:5 acid. The solution is kept cold and ammonium acetate added until neutral to Congo Red test paper. After allowing to stand for one hour, the coupling mixture is diluted with water, and the dye is filtered, washed and dried in air to produce intermediate dyes.

PREPARATION C Diazotization and Coupling of 5-Amino-3-Acetyl 1,2,4-thiadiazole

5-Amino-3-acetyl-1,2,4-thiadiazole 0.055 m. is diazotized exactly as described in (b) above and a 0.005 m aliquot coupled to a 0.005 m. portion of each of the Couplers 1-11 in the manner of (b).

PREPARATION D Diazotization and Coupling of 5-Amino-3-Acetyl-4-Cyanoisothiazole

To 25 ml. of concentrated H₂ SO₄ is added 3.6 g. of NaNO₂ allowing the temperature to rise. The solution is cooled and 50 ml. of 1:5 acid is added below 10° C. Stirring is continued and 0.055 m. of 5-amino-3-acetyl-4-cyanoisothiazole is added below 5° C., followed by an additional 50 ml. of 1:5 acid. After stirring at 0°-5° C. for two hours, a 0.005 m. aliquot of the diazonium salt is cooled to 0.005 m. of each of the Couplers 1-11 as previously described.

PREPARATION E Diazotization and Coupling of 2-Amino-5-Acetyl-4-Methylthiazole

Sodium nitrite (3.6 g.) is added portionwise to 25 ml of concentrated H₂ SO₄. The solution is cooled and 100 ml of 1:5 acid is added below 15° C. The mixture is cooled and 0.055 m. of 2-amino-5-acetyl-4-methylthiazole is added below 10° C. After stirring at 0°-5° C. for two hours, a 0.005 m. aliquot of the diazonium salt is coupled to 0.005 m. of each of the Couplers 1-11 to produce intermediate red to violet dyes.

PREPARATION F Sulfonation of Dye Containing an N-(Aralkylamino) Group

The dye from 2-amino-5-acetyl-1,3,4-thiadiazole and N-benzyl-N-ethylaniline (1.7 g.) is added portionwise to 15 ml. of concentrated H₂ SO₄ over 20 min., allowing the temperature to rise to 30° C. The reaction mixture is then heated at 70° C., when the reaction is completed as evidenced by thin-layer chromatography. After the reaction mixture is drowned on ice-water mixture, 50% NaOH is added until the pH is about 7. The dye is collected by filtration, washed with water, and dried in air. The structure is as follows:

EXAMPLE ##STR5##

A mixture of compound (I) (2 g.), benzaldehyde (1.5 g.), acetic acid (25 ml.) and concentrated sulphuric acid (5 ml.) was stirred at 100° C. for 1.5 hours. The reaction mixture was poured into cold water and the product dye (II) filtered off, washed with water and dried. Compound (I) had previously been prepared by diazotizing 2-amino-5-acetyl-1,3,4-thiadiazole and coupling with N,N-diethyl-m-toluidine by the above procedures. The dye (II) when applied to nylon, polyester and other synthetic fibres by known techniques gave bright, bluish red shades with good dyeing and fastness properties.

By using the methods described hereinabove, the following dyes are obtained.

                                      TABLE 1                                      __________________________________________________________________________      ##STR6##                                                                       ##STR7##                                                                      R.sub. 1 on D R.sub.5                                                                             R.sub.1 on C R.sub.2        R.sub.7                         __________________________________________________________________________     H             H    H            H              H                               4-NO.sub.2    H    2-CH.sub.3   C.sub.2 H.sub.5                                                                               Ph                              4-CN          H    5-COCH.sub.3 C.sub.2 H.sub.5                                                                               C.sub.6 H.sub.11                5-COCH.sub.3  H    5-OCH.sub.3  CH.sub.2C.sub.6 H.sub.4 -p-SO.sub.4                                                           CH.sub.2CHCH.sub.2              4-COPh        CH.sub.3                                                                            5-SO.sub.3 Na                                                                               H              CH.sub.2 OOCC.sub.2                                                            H.sub.5                         2,4-di-COOH   CH.sub.3                                                                            5-OCH.sub.2 CH.sub.2 SO.sub.4 K                                                             CH.sub.2C.sub.6 H.sub.104-SO.sub.3                                                            C.sub.6 H.sub.4 -p-OOCCH.su                                                    b.3                             4-OOCCH.sub.3 CH.sub.3                                                                            5-OCH.sub.2 CH.sub.2 SO.sub.4 N H(Et).sub.3                                                 H              C.sub.6 H.sub.104-CH.sub.3                                                     8                               4-NHCOCH.sub.3                                                                               CH.sub.3                                                                            2-CH.sub.3   CH.sub.2C.sub.6 H.sub.4 -p-SO.sub.4 N                                          H(Et).sub.3    CH.sub.2 CH.sub.2 (C.sub.4                                                     H.sub.4 O.sub.2 N)              4-NHCOPh      CH.sub.3                                                                            2-Ph         CH.sub.3       CH.sub.2 CH.sub.2 NO.sub.2      4-C.sub.2 H.sub.5                                                                            CH.sub.3                                                                            2-NO.sub.2   CH.sub.3       C.sub.6 H.sub.4 -p-NO.sub.2     4-Ph          H    2-OCH.sub.3  CH.sub.3       CH.sub.2 NHOCCH.sub.3           2-SO.sub.3 Na H    3-CH.sub.3   Et             Et                              2,5-di-Cl     H    5-NHCOCH.sub.3                                                                              C.sub.2 H.sub.5                                                                               CH.sub.2 NHSO.sub.2                                                            CH.sub.3                        2-Cl4-SO.sub.2 CH.sub.3                                                                      H    3-NHSO.sub.2 CH.sub.3                                                                       C.sub.2 H.sub.5                                                                               C.sub.6 H.sub.4 -p-NHOCCH.s                                                    ub.3                            4-NHSO.sub.2 CH.sub.3                                                                        H    3-COOCH.sub.3                                                                               C.sub.2 H.sub.5                                                                               C.sub.6 H.sub.4 -p-NHSO.sub                                                    .2 CH.sub.3                     4-COOCH.sub.3 H    3-COOH       C.sub.2 H.sub.5                                                                               C.sub.6 H.sub.104-NHCOCH.su                                                    b.3                             2-OCH.sub.3   C.sub.2 H.sub.5                                                                     2-Cl         CH.sub.2 CH.sub.2 Cl                                                                          CH.sub.2 CH.sub.2 Cl            4-OC.sub.2 H.sub.5                                                                           C.sub.2 H.sub.5                                                                     2,6-di-Br    C.sub.6 H.sub.4 -p-Br                                                                         C.sub.6 H.sub.4p-Br             4-SO.sub.3 Na C.sub.2 H.sub.5                                                                     2,6-di-Br    C.sub.6 H.sub.4 -p-CN                                                                         C.sub.6 H.sub.4p-CN             2-SO.sub.3 Na C.sub.2 H.sub.5                                                                     2-OCH.sub.35-NHCOCH.sub.3                                                                   CH.sub.2 CH.sub.2 CN                                                                          CH.sub.2 CH.sub.2 CN            2-OCH.sub.34-SO.sub.3 K                                                                      H    2-CH.sub.2 OOCCH.sub.3                                                                      CH.sub.2 CH.sub.2 OC.sub.2 H.sub.5                                                            CH.sub.2 CH.sub.2 OC.sub.2                                                     H.sub.5                         4-OCH.sub.2 CH.sub.2 OSO.sub.3 K                                                             H    2-CH.sub.2 Cl                                                                               CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2                                           OC.sub.2 H.sub.5                                                                              CH.sub.2 CH.sub.2                                                              OCH.sub.2 CH.sub.2                                                             OC.sub.2 H.sub.5                2-SO.sub.3 Na5-Cl                                                                            H    2-CN         CH.sub.2 Ph    CH.sub.2C.sub.6 H.sub.4                                                        -p-SO.sub.4 N H(Et).sub.3       4-Cl          H    2-OOCCH.sub.3                                                                               CH.sub.2 C.sub.6 H.sub.11                                                                     CH.sub.2 C.sub.6 H.sub.104-                                                    SO.sub.3 Na                     4-OH          H    5-COOH       H              C.sub.6 H.sub.4 -o-OH           4-CH.sub.2 OOCCH.sub.3                                                                       C.sub.3 H.sub.7n                                                                    5-OH         C.sub.2 H.sub.5                                                                               CH.sub.2 CH.sub.2 OH            4-SO.sub.3 K  C.sub.3 H.sub.7n                                                                    5-CH.sub.2 CHCH.sub.2                                                                       CH.sub.2 CH.sub.2SO.sub.3 K                                                                   CH.sub.2 CH.sub.2SO.sub.3                                                      K                               4-OPh         H    2-CH.sub.3   H              CH.sub.2C.sub.6 H.sub.4                                                        -p-OSO.sub.3 K                  4-NO.sub.2    H    5-COCH.sub.3 H              CH.sub.2 OPh                    4-C.sub.6 H.sub.4 -p-CH.sub.3                                                                C.sub.2 H.sub.5                                                                     5-C.sub.6 H.sub.4 -p-CH.sub.3                                                               CH.sub.2 CH.sub.2 Cl                                                                          CH.sub.2 CH.sub.2 Cl            4-C.sub.6 H.sub.4 p-CH.sub.2 CHCH.sub.2                                                      C.sub.2 H.sub.5                                                                     5-C.sub.6 H.sub.4 -p-CH.sub.2 CHCH.sub.2                                                    C.sub.6 H.sub.4 -p-Br                                                                         C.sub.6 H.sub.4 -p-Br           4-OCH.sub.2 CH.sub.2 NO.sub.2                                                                C.sub.2 H.sub.5                                                                     5-OCH.sub.2 CH.sub.2 NO.sub.2                                                               C.sub. 6 H.sub.4 -p-CN                                                                        C.sub.6 H.sub.4 -p-CN           2-CH.sub.2 NHCOCH.sub.3                                                                      C.sub.2 H.sub.5                                                                     2-CH.sub.2 NHCOCH.sub.3                                                                     CH.sub.2 CH.sub.2 CN                                                                          CH.sub.2 CH.sub.2 CN            4-CH.sub.2 NHSO.sub.2 C.sub.2 H.sub.5                                                        H    5-CH.sub.2 NHSO.sub.2 C.sub.2 H.sub.5                                                       CH.sub.2 CH.sub.2 OC.sub.2 H.sub.5                                                            CH.sub.2 CH.sub.2 OC.sub.2                                                     H.sub.5                         4-CH.sub.2 CH.sub.2 Cl                                                                       H    5-CH.sub.2 CH.sub.2 Cl                                                                      CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2                                           OC.sub.2 H.sub.5                                                                              CH.sub.2 CH.sub.2 OCH.sub.2                                                     CH.sub.2 OC.sub.2                                                             H.sub.5                         2,6-di-CH.sub.2 CN                                                                           H    2,6-di-CH.sub.2 CN                                                                          CH.sub.2 Ph    CH.sub.2 Ph                     4-CH.sub.2 CH.sub.2 OC.sub.2 H.sub.5                                                         H    5-CH.sub.2 CH.sub.2 OC.sub.2 H.sub.5                                                        CH.sub.2 C.sub.6 H.sub.11                                                                     CH.sub.2 C.sub.6 H.sub.11       4-CH.sub.2 C.sub.6 H.sub.5                                                                   H    5-COOH       H              C.sub.6 H.sub.4 -o-OH           4-CH.sub.2 C.sub.6 H.sub.11                                                                  C.sub.3 H.sub.7n                                                                    5-CH.sub.2 C.sub.6 H.sub.11                                                                 C.sub.2 H.sub.5                                                                               CH.sub.2 CH.sub.2 OH            4-CH.sub.2 CH(OH)CH.sub.2 OH                                                                 C.sub.3 H.sub.7n                                                                    5-CH.sub.2 CH(OH)CH.sub.2 OH                                                                CH.sub.2 CH.sub.2 SO.sub.3 K                                                                  CH.sub.2 CH.sub.2SO.sub.3                                                      K                               4-CH.sub.2 CH.sub.2SO.sub.3 K                                                                H    5-CH.sub.2 CH.sub.2SO.sub.3 K                                                               H              C.sub.6 H.sub.4 -p-OSO.sub.                                                    3 K                             4-CH.sub.2 OC.sub.6 H.sub.5                                                                  H    5-CH.sub.2 OC.sub.6 H.sub.5                                                                 H              CH.sub.2 OPh                    4-CH.sub.2 OOCC.sub.6 H.sub.5                                                                H    5-CH.sub.2 OOCC.sub.6 H.sub.5                                                               H              CH.sub.2 SO.sub.2 NHPh          5-CH.sub.2 COOCH.sub.3                                                                       H    5-CH.sub.2 COOCH.sub.3                                                                      CH.sub.2 SO.sub.2 NHCH.sub.3                                                                  CH.sub.2 SO.sub.2 NHCH.sub.                                                    3                               4-C.sub.6 H.sub.4 -p-SO.sub.2 N(C.sub.2 H.sub.5).sub.2                                       H    5-C.sub.6 H.sub.4p-SO.sub.2 N(C.sub.2 H.sub.5).sub.2                                        H              C.sub.6 H.sub.4 -p-SO.sub.2                                                     NHCH.sub.3                     4-CH.sub.2 CH.sub.2 NHCOOCH.sub.3                                                            H    5-CH.sub.2 CH.sub.2 NHCOOCH.sub.3                                                           CH.sub.2 COOCH.sub.3                                                                          CH.sub.2 COOCH.sub.3            4-CH.sub.2 NHCONHCH.sub.3                                                                    H    5-CH.sub.2 NHCONHCH.sub.3                                                                   H              CH.sub.2 SO.sub.2 N(CH.sub.                                                    3).sub.2                        4-CH.sub.2 CONH.sub.2                                                                        H    5-CH.sub.2 CONH.sub.2                                                                       C.sub.2 H.sub.5                                                                               C.sub.6 H.sub.4 -p-NHCOOCH.                                                    sub.3                           5-CH.sub.2 CONHCH.sub.3                                                                      C.sub.4 H.sub.9n                                                                    5-CONH.sub.2 C.sub.2 H.sub.5                                                                               CH.sub.2 CH.sub. 2                                                             CONH.sub.2                      4-CH.sub.2 CON(CH.sub.3).sub.2                                                               H    3-SO.sub.2 NH.sub.2                                                                         C.sub.2 H.sub.5                                                                               C.sub.6 H.sub.4 -p-CONHCH.s                                                    ub.3                            4-CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2 OC.sub.2 H.sub.5                                      H    5-SO.sub.2 NHCH.sub.3                                                                       C.sub.2 H.sub.5                                                                               C.sub.6 H.sub.4 -p-SCH.sub.                                                    3                               4-CH.sub.2 SC.sub.2 H.sub.5                                                                  H    5-SO.sub.2 N(C.sub.2 H.sub.5).sub.2                                                         CH.sub.2 CH.sub.2 SCH.sub.3                                                                   CH.sub.2 CH.sub.2 SCH.sub.3     5-CH.sub.2 SC.sub.6 H.sub.5                                                                  H    5-SO.sub.3 C.sub.6 H.sub.5                                                                  H              CH.sub.2C.sub.6 H.sub.4                                                        -p-SCH.sub.3                    4-CH.sub.2 SO.sub.2 C.sub.2 H.sub.5                                                          CH.sub.3                                                                            5-SCH.sub.3  CH.sub.2 SO.sub.2 C.sub.2 H.sub.5                                                             CH.sub.2 SO.sub.2 C.sub.2                                                      H.sub.5                         2,4-di-CH.sub.2 SO.sub.2 C.sub.6 H.sub.5                                                     CH.sub.3                                                                            2,5-di-SCN   H              CH.sub.2 SO.sub.2 Ph            4-C.sub.6 H.sub.3 -o, -p-di-CN                                                               CH.sub.3                                                                            5-SO.sub.2 C.sub.6 H.sub.5                                                                  H              CH.sub.2 CH.sub.2 OSO.sub.3                                                     K                              4-C.sub.6 H.sub.2 -o, .sub.--m, -p-tri-Cl                                                    CH.sub.3                                                                            2-CHO6-CN    H              C.sub.6 H.sub.4 -p-OSO.sub.                                                    3 K                             2,6-di-OSO.sub.3 Na                                                                          CH.sub.3                                                                            5-CONHC.sub.2 H.sub.5                                                                       H              CH.sub.2(C.sub.8 H.sub.4                                                       O.sub.2 N)                      H             H    5-CON(C.sub.2 H.sub.5).sub.2                                                                C.sub.2 H.sub.5                                                                               C.sub.2 H.sub.5                 H             H    3-C.sub.6 H.sub.11                                                                          C.sub.2 H.sub.5                                                                               C.sub.2 H.sub.5                 5-CH.sub.2 (C.sub.8 H.sub.4 O.sub.2 N)                                                       H    3-SC.sub.6 H.sub.5                                                                          C.sub.2 H.sub.5                                                                               C.sub.2 H.sub.5                 5-CH.sub.2 (C.sub.4 H.sub.3 O)                                                               H    6-NHSO.sub.2 C.sub.6 H.sub.5                                                                C.sub.2 H.sub.5                                                                               C.sub.2 H.sub.5                 __________________________________________________________________________

                                      TABLE 2                                      __________________________________________________________________________      ##STR8##                                                                       ##STR9##                                                                      R.sub.1 on D   R.sub.5                                                                              R.sub.1 on C   R.sub.3                                                                            R.sub.4                                                                            R.sub.8                                                                            R.sub.7                        __________________________________________________________________________     H              H     H              H   H   H   H                              4-NO.sub.2     H     7-CH.sub.3     CH.sub.3                                                                           CH.sub.3                                                                           CH.sub.3                                                                           Ph                             4-CN           H     5-COCH.sub.3   CH.sub.3                                                                           CH.sub.3                                                                           H   C.sub.6 H.sub.11               5-COCH.sub.3   H     5-OCH.sub.3    CH.sub.3                                                                           CH.sub.3                                                                           H   CH.sub.2CHCH.sub.2             4-COPh         CH.sub.3                                                                             7-SO.sub.3 Na  CH.sub.3                                                                           CH.sub.3                                                                           H   CH.sub.2 OOCC.sub.2                                                            H.sub.5                        2,4-di-COOH    CH.sub.3                                                                             7-OCH.sub.2 CH.sub.2 SO.sub.4 K                                                               CH.sub.3                                                                           CH.sub.3                                                                           H   C.sub.6 H.sub.4 -p-OOCCH.s                                                     ub.3                           4-OOCCH.sub.3  CH.sub.3                                                                             7-OCH.sub.2 CH.sub.2 SO.sub.4 N H(Et).sub.3                                                   CH.sub.3                                                                           CH.sub.3                                                                           H   C.sub.6 H.sub.104-CH.sub.3     4-NHCOCH.sub.3 CH.sub.3                                                                             7-CH.sub.3     CH.sub.3                                                                           H   H   CH.sub.2 CH.sub.2                                                              (C.sub.4 H.sub.4 O.sub.2                                                       N)                             4-NHCOPh       CH.sub.3                                                                             7-Ph           CH.sub.3                                                                           H   H   CH.sub.2 CH.sub.2                                                              NO.sub.2                       4-C.sub.2 H.sub.5                                                                             CH.sub.3                                                                             7-NO.sub.2     CH.sub.3                                                                           H   H   C.sub.6 H.sub.4 -p-NO.sub.                                                     2                              4-Ph           H     7-OCH.sub.3    CH.sub.3                                                                           H   H   CH.sub.2 NHOCCH.sub.3          2,5-di-Cl      H     7-NHCOCH.sub.3 CH.sub.3                                                                           H   H   CH.sub.2 NHSO.sub.2                                                            CH.sub.3                       2-Cl4-SO.sub.2 CH.sub.3                                                                       H     7-NHSO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                           H   H   C.sub.6 H.sub.4 -p-NHOCCH.                                                     sub.3                          4-NHSO.sub.2 CH.sub.3                                                                         H     7-COOCH.sub.3  CH.sub.3                                                                           C.sub.2 H.sub.5                                                                    C.sub.2 H.sub.5                                                                    C.sub.6 H.sub.4 -p-NHSO.su                                                     b.2 CH.sub.3                   4-COOCH.sub.3  H     7-COOH         H   H   H   C.sub.6 H.sub.104-NHOCCH.s                                                     ub.3                           2-OCH.sub.3    C.sub.2 H.sub.5                                                                      7-Cl           CH.sub.3                                                                           CH.sub.3                                                                           CH.sub.3                                                                           CH.sub.2 CH.sub.2 Cl           4-OC.sub.2 H.sub.5                                                                            C.sub.2 H.sub.5                                                                      5,7-di-Br      CH.sub.3                                                                           CH.sub.3                                                                           H   C.sub.6 H.sub.4 -p-Br          4-SO.sub.3 Na  C.sub.2 H.sub.5                                                                      5,7-di-Br      CH.sub.3                                                                           CH.sub.3                                                                           H   C.sub.6 H.sub.4  -p-CN         2-SO.sub.3 Na  C.sub.2 H.sub.5                                                                      5-OCH.sub.37-NHCOCH.sub.3                                                                     CH.sub.3                                                                           CH.sub.3                                                                           H   CH.sub.2 CH.sub.2 CN           2-OCH.sub.34-SO.sub.3 K                                                                       H     7-CH.sub.2 OOCCH.sub.3                                                                        CH.sub.3                                                                           CH.sub.3                                                                           H   CH.sub.2 CH.sub.2                                                              OC.sub.2 H.sub.5               4-OCH.sub.2 CH.sub.2 OSO.sub.3 K                                                              H     7-CH.sub.2 Cl  CH.sub.3                                                                           CH.sub.3                                                                           H   CH.sub.2 CH.sub.2                                                              OCH.sub.2 CH.sub.2                                                             OC.sub.2 H.sub.5               2-SO.sub.3 Na5-Cl                                                                             H     7-CN           CH.sub.3                                                                           H   H   CH.sub.2 Ph                    4-Cl           H     7-OOCCH.sub.3  CH.sub.3                                                                           H   H   CH.sub.2 C.sub.6 H.sub.11      4-OH           H     5-COOH         CH.sub.3                                                                           H   H   C.sub.6 H.sub.4 -o-OH          4-CH.sub.2 OOCCH.sub.3                                                                        C.sub.3 H.sub.7n                                                                     5-OH           CH.sub.3                                                                           H   H   CH.sub.2 CH.sub.2 OH           4-SO.sub.3 K   C.sub.3 H.sub.7n                                                                     5-CH.sub.2 CHCH.sub.2                                                                         CH.sub.3                                                                           H   H   CH.sub.2 CH.sub.2SO.sub.3                                                      K                              4-OPh          H     7-CH.sub.3     CH.sub.3                                                                           H   H   C.sub.6 H.sub.4 -p-OSO.sub                                                     .3 K                           4-NO.sub.2     H     7-COCH.sub.3   CH.sub.3                                                                           C.sub.2 H.sub.5                                                                    C.sub.2 H.sub.5                                                                    CH.sub.2 OPh                   5-CN           H     7-OCH.sub.3    H   H   H   CH.sub.2 SO.sub.2 NHPh         4-COCH.sub.3   H     7-SO.sub.3 Na  CH.sub.3                                                                           CH.sub.3                                                                           CH.sub.3                                                                           CH.sub.2 SO.sub.2                                                              NHCH.sub.3                     5-CH.sub.3     H     7-OCH.sub.2 CH.sub.2 SO.sub.4 K                                                               CH.sub.3                                                                           CH.sub.3                                                                           H   C.sub.6 H.sub.4 -p-SO.sub.                                                     2 NHCH.sub.3                   5-Ph           H     7-OCH.sub.2 CH.sub.2 SO.sub.3 K                                                               CH.sub.3                                                                           CH.sub.3                                                                           H   CH.sub.2 COOCH.sub.3           5-OCH.sub.3    H     7-CH.sub.3     CH.sub.3                                                                           CH.sub.3                                                                           H   CH.sub.2 SO.sub.2                                                              N(CH.sub.3).sub.2              4,5-di-Br      H     7-Ph           CH.sub.3                                                                           CH.sub.3                                                                           H   C.sub.6 H.sub.4 -p-NHCOOCH                                                     .sub.3                         5-COOH         C.sub.4 H.sub.9n                                                                     7-NO.sub.2     H   H   H   CH.sub.2 CH.sub.2                                                              CONH.sub.2                     H              H     7-OCH.sub.3    CH.sub.3                                                                           CH.sub.3                                                                           CH.sub.3                                                                           C.sub.6 H.sub.4 -p-CONHCH.                                                     sub.3                          4-NO.sub.2     H     7-NHCOCH.sub.3 CH.sub.3                                                                           CH.sub.3                                                                           H   C.sub.6 H.sub.4 -p-SCH.sub                                                     .3                             4-CN           H     7-NHSO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                           CH.sub.3                                                                           H   CH.sub.2 CH.sub.2                                                              SCH.sub.3                      5-COCH.sub.3   H     7-COOCH.sub.3  CH.sub.3                                                                           CH.sub.3                                                                           H   CH.sub.2C.sub.6 H.sub.4                                                        --SCH.sub.3                    4-COPh         CH.sub.3                                                                             7-COOH         CH.sub.3                                                                           CH.sub.3                                                                           H   CH.sub.2 SO.sub.2 C.sub.2                                                      H.sub.5                        2,4-di-COOH    CH.sub.3                                                                             7-Cl           CH.sub.3                                                                           CH.sub.3                                                                           H   CH.sub.2 SO.sub.2 Ph           4-OOCCH.sub.3  CH.sub.3                                                                             5,7-di-Br      CH.sub.3                                                                           H   H   CH.sub.2 CH.sub.2                                                              OSO.sub.3 K                    4-NHCOCH.sub.3 CH.sub.3                                                                             5,7-di-Br      CH.sub.3                                                                           H   H   C.sub.6 H.sub.4 -p-OSO.sub                                                     .3 K                           4-NHCOPh       CH.sub.3                                                                             5-OCH.sub.37-NHCOCH.sub.3                                                                     CH.sub.3                                                                           H   H   CH.sub.2 (C.sub.8 H.sub.4                                                      O.sub.2 N)                     4-CH.sub.2 CHCH.sub.2                                                                         H     7-NHCOCH.sub.3 C.sub.2 H.sub.5                                                                    H   H   C.sub.2 H.sub.5                H              CH.sub.3                                                                             7-OCPh         C.sub.2 H.sub.5                                                                    H   H   C.sub.2 H.sub.5                4-CONH.sub.2   H     7-CH.sub.2 CONHCH.sub.3                                                                       H   H   H   H                              3-SO.sub.2 NH.sub.2                                                                           H     7-CH.sub.3 CON(CH.sub.3).sub.2                                                                CH.sub.3                                                                           CH.sub.3                                                                           CH.sub.3                                                                           Ph                             4-SO.sub.2 NHCH.sub.3                                                                         H     7-CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2 OC.sub.2                                H.sub.5        CH.sub.3                                                                           CH.sub.3                                                                           H   C.sub.6 H.sub.11               4-SO.sub.2 N(C.sub.2 H.sub.5).sub.2                                                           H     7-CH.sub.2 SC.sub.2 H.sub.5                                                                   CH.sub.3                                                                           CH.sub.3                                                                           H   CH.sub.2CHCH.sub.2             4-SO.sub.3 C.sub.6 H.sub.5                                                                    CH.sub.3                                                                             7-CH.sub.2 SC.sub.6 H.sub.5                                                                   CH.sub.3                                                                           CH.sub.3                                                                           H   CH.sub.2 OOCC.sub.2                                                            H.sub.5                        4-SCH.sub.3    CH.sub.3                                                                             7-CH.sub.2 SO.sub.2 C.sub.2 H.sub.5                                                           CH.sub.3                                                                           CH.sub.3                                                                           H   C.sub.6 H.sub.4 -p-OOCCH.s                                                     ub.3                           2,4-di-SCN     CH    7-CH.sub.2 SO.sub.2 C.sub.6 H.sub.5                                                           CH.sub.3                                                                           CH.sub.3                                                                           H   C.sub.6 H.sub.104-CH.sub.3     4-SO.sub.2 C.sub.6 H.sub.4                                                                    CH.sub.3                                                                             7-C.sub.6 H.sub.3 -o, -p-di-CN                                                                CH.sub.3                                                                           H   H   CH.sub.2 CH.sub.2(C.sub.4                                                      H.sub.4 O.sub.2 N)             2-CHO4-CN      CH.sub.3                                                                             7-C.sub.6 H.sub.2 -o, .sub.--m, -p-tri-Cl                                                     CH.sub.3                                                                           H   H   CH.sub.2 CH.sub.2                                                              NO.sub.2                       4-CONHC.sub.2 H.sub.5                                                                         CH.sub.3                                                                             5,7-di-OSO.sub.3 N H(CH.sub.3).sub.3                                                          CH.sub.3                                                                           H   H   C.sub.6 H.sub.4 -p-NO.sub.                                                     2                              4-CON(C.sub.2 H.sub.5).sub.2                                                                  H     5,7-di-OSO.sub.3 Na                                                                           CH.sub.3                                                                           H   H   CH.sub.2 NHOCCH.sub.3          3-C.sub.6 H.sub.11                                                                            H     5,7-di-SO.sub.3 N H(CH.sub. 3).sub.3                                                          CH.sub.3                                                                           H   H   CH.sub.2 NHSO.sub.2                                                            CH.sub.3                       3-SC.sub.6 H.sub.5                                                                            H     7-OSO.sub.3 N H(CH.sub.3).sub.3                                                               CH.sub.3                                                                           H   H   C.sub.6 H.sub.4 -p-NHOCCH.                                                     sub.3                          4-NHSO.sub.2 C.sub.6 H.sub.5                                                                  H     5,7-di-OSO.sub.3 Na                                                                           CH.sub.3                                                                           C.sub.2 H.sub.5                                                                    C.sub.2 H.sub.5                                                                    C.sub.6 H.sub.4 -p-NHSO.su                                                     b.2 CH.sub.3                   4-SC.sub.6 H.sub.11                                                                           H     7-SC.sub.6 H.sub.11                                                                           H   H   H   C.sub.6 H.sub.104-NHOCCH.s                                                     ub.3                           4-C.sub.6 H.sub.4 -p-CH.sub.3                                                                 C.sub.2 H.sub.5                                                                      7-C.sub.6 H.sub.4 -p-CH.sub.3                                                                 CH.sub.3                                                                           CH.sub.3                                                                           CH.sub.3                                                                           CH.sub.2 CH.sub.2 Cl           4-C.sub.6 H.sub.4 -p-CH.sub.2 CHCH.sub.2                                                      C.sub.2 H.sub.5                                                                      7-C.sub.6 H.sub.4 -p-CH.sub.2 CHCH.sub.2                                                      CH.sub.3                                                                           CH.sub.3                                                                           H   C.sub.6 H.sub.4 -p-Br          4-OCH.sub.2 CH.sub.2 NO.sub.2                                                                 C.sub.2 H.sub.5                                                                      7-OCH.sub.2 CH.sub.2 NO.sub.2                                                                 CH.sub.3                                                                           CH.sub.3                                                                           H   C.sub.6 H.sub.4 -p-CN          2-CH.sub.2 NHCOCH.sub.3                                                                       C.sub.2 H.sub.5                                                                      7-CH.sub.2 NHCOCH.sub.3                                                                       CH.sub.3                                                                           CH.sub.3                                                                           H   CH.sub.2 CH.sub.2 CN           4-CH.sub.2 NHSO.sub.2 C.sub.2 H.sub.5                                                         H     7-CH.sub.2 NHSO.sub.2 C.sub.2 H.sub.5                                                         CH.sub.3                                                                           CH.sub.3                                                                           H   CH.sub.2 CH.sub.2                                                              OC.sub.2 H.sub.5               4-CH.sub.2 CH.sub.2 Cl                                                                        H     7-CH.sub.2 CH.sub.2 Cl                                                                        CH.sub.3                                                                           CH.sub.3                                                                           H   CH.sub.2 CH.sub.2                                                              OCH.sub.2 CH.sub.2                                                             OC.sub.2 H.sub.5               2,6-di-CH.sub.2 CN                                                                            H     5,7-di-CH.sub.2 CN                                                                            CH.sub.3                                                                           H   H   CH.sub.2 Ph                    4-CH.sub.2 CH.sub.2 OC.sub.2 H.sub.5                                                          H     7-CH.sub.2 CH.sub.2 OC.sub.2 H.sub.5                                                          CH.sub.3                                                                           H   H   CH.sub.2 C.sub.6 H.sub.11      4-CH.sub.2 C.sub.6 H.sub.5                                                                    H     7-COOH         CH.sub.3                                                                           H   H   C.sub.6 H.sub.4 -o-OH          4-CH.sub.2 C.sub.6 H.sub.11                                                                   C.sub.3 H.sub.7n                                                                     7-CH.sub.2 C.sub.6 H.sub.11                                                                   CH.sub.3                                                                           H   H   CH.sub.2 CH.sub.2 OH           4-CH.sub.2 CH(OH)CH.sub.2 OH                                                                  C.sub.3 H.sub.7n                                                                     7-CH.sub.2 CH(OH)CH.sub.2 OH                                                                  CH.sub.3                                                                           H   H   CH.sub.2 CH.sub.2SO.sub.3                                                      K                              4-CH.sub.2 CH.sub.2SO.sub.3 K                                                                 H     7-CH.sub.2 CH.sub.2SO.sub.3 K                                                                 CH.sub.3                                                                           H   H   C.sub.6 H.sub.4 -p-OSO.sub                                                     .3 K                           4-CH.sub.2 OC.sub.6 H.sub.5                                                                   H     7-CH.sub.2 OC.sub.6 H.sub.5                                                                   CH.sub.3                                                                           C.sub.2 H.sub.5                                                                    C.sub.2 H.sub.5                                                                    CH.sub.2 OPh                   4-CH.sub.2 OOCC.sub.6 H.sub.5                                                                 H     7-CH.sub.2 OOCC.sub.6 H.sub.5                                                                 H   H   H   CH.sub.2 SO.sub.2 NHPh         5-CH.sub.2 COOCH.sub.3                                                                        H     7-CH.sub.2 COOCH.sub.3                                                                        CH.sub.3                                                                           CH.sub.3                                                                           CH.sub.3                                                                           CH.sub.2 SO.sub.2                                                              NHCH.sub.3                     4-C.sub.6 H.sub.4 -p-SO.sub.2 N(C.sub.2 H.sub.5).sub.2                                        H     7-C.sub.6 H.sub.4 -p-SO.sub.2 N(C.sub.2 H.sub.5).sub.                          2              CH.sub.3                                                                           CH.sub.3                                                                           H   C.sub.6 H.sub.4 -p-SO.sub.                                                     2 NHCH.sub.3                   4-CH.sub.2 CH.sub.2 NHCOOCH.sub.3                                                             H     7-CH.sub.2 CH.sub.2 NHCOOCH.sub.3                                                             CH.sub.3                                                                           CH.sub.3                                                                           H   CH.sub.2 COOCH.sub.3           4-CH.sub.2 NHCONHCH.sub.3                                                                     H     7-CH.sub.2 NHCONHCH.sub.3                                                                     CH.sub.3                                                                           CH.sub.3                                                                           H   CH.sub.2 SO.sub.2                                                              N(CH.sub.3).sub.2              4-CH.sub.2 CONH.sub.2                                                                         H     7-CH.sub.2 CONH.sub.2                                                                         CH.sub.3                                                                           CH.sub.3                                                                           H   C.sub.6                                                                        H.sub.4 -p-NHCOOCH.sub.3       5-CH.sub.2 CONHCH.sub.3                                                                       C.sub.4 H.sub.9n                                                                     7-CONH.sub.2   H   H   H   CH.sub.2 CH.sub.2                                                              CONH.sub.2                     4-CH.sub.2 CON(CH.sub.3).sub.2                                                                H     7-SO.sub.2 NH.sub.2                                                                           CH.sub.3                                                                           CH.sub.3                                                                           CH.sub.3                                                                           C.sub.6 H.sub.4 -p-CONHCH.                                                     sub.3                          4-CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2 OC.sub.2 H.sub.5                                       H     7-SO.sub.2 NHCH.sub.3                                                                         CH.sub.3                                                                           CH.sub.3                                                                           H   C.sub.6 H.sub.4 -p-SCH.sub                                                     .3                             4-CH.sub.2 SC.sub.2 H.sub.5                                                                   H     7-SO.sub.2 N(C.sub.2 H.sub.5).sub.2                                                           CH.sub.3                                                                           CH.sub.3                                                                           H   CH.sub.2 CH.sub.2                                                              SCH.sub.3                      5-CH.sub.2 SC.sub.6 H.sub.5                                                                   H     7-SO.sub.3 C.sub.6 H.sub.5                                                                    CH.sub.3                                                                           CH.sub.3                                                                           H   CH.sub.2C.sub.6 H.sub.4                                                        -p-SCH.sub.3                   4-CH.sub.2 SO.sub.2 C.sub.2 H.sub.5                                                           CH.sub.3                                                                             7-SCH.sub.3    CH.sub.3                                                                           CH.sub.3                                                                           H   CH.sub.2 SO.sub.2 C.sub.2                                                      H.sub.5                        2,4-di-CH.sub.2 SO.sub.2 C.sub.6 H.sub.5                                                      CH.sub.3                                                                             5,7-di-SCN     CH.sub.3                                                                           CH.sub.3                                                                           H   CH.sub.2 SO.sub.2 Ph           4-C.sub.6 H.sub.3 -o, - p-di-CN                                                               CH.sub.3                                                                             7-SO.sub.2 C.sub.6 H.sub.5                                                                    CH.sub.3                                                                           H   H   CH.sub.2 CH.sub.2                                                              OSO.sub.3 K                    4-C.sub.6 H.sub.2 -o, .sub.--m, -p-tri-Cl                                                     CH.sub.3                                                                             5-CHO7-CN      CH.sub.3                                                                           H   H   C.sub.6 H.sub.4 -p-OSO.sub                                                     .3 K                           2,6-di-OSO.sub.3 Na                                                                           CH.sub.3                                                                             7-CONHC.sub.2 H.sub.5                                                                         CH.sub.3                                                                           H   H   CH.sub.2 (C.sub.8 H.sub.4                                                      O.sub.2 N)                     H              H     7-CON(C.sub.2 H.sub.5).sub.2                                                                  CH.sub.3                                                                           H   H   C.sub.2 H                      H              H     7-C.sub.6 H.sub.11                                                                            CH.sub.3                                                                           H   H   C.sub.2 H.sub.5                5-CH.sub.2 (C.sub.8 H.sub.4 O.sub.2 N)                                                        H     7-SC.sub.6 H.sub.5                                                                            CH.sub.3                                                                           H   H   C.sub.2 H.sub.5                5-CH.sub.2 (C.sub.4 H.sub.3 O)                                                                H     7-NHSO.sub.2 C.sub.6 H.sub.5                                                                  CH.sub.3                                                                           C.sub.2 H.sub.5                                                                    C.sub.2 H.sub.5                                                                    C.sub.2 H.sub.5                __________________________________________________________________________

                                      TABLE 3                                      __________________________________________________________________________      ##STR10##                                                                      ##STR11##                                                                     R.sub.1 on D  R.sub.5                                                                             R.sub.1 on C  R.sub.3                                                                             R.sub.7                                  __________________________________________________________________________     H             H    H             H    H                                        4-NO.sub.2    H    6-CH.sub.3    CH.sub.3                                                                            Ph                                       4-CN          H    6-COCH.sub.3  C.sub.2 H.sub.5                                                                     C.sub.6 H.sub.11                         5-COCH.sub.3  H    6-OCH.sub.3   H    CH.sub.2CHCH.sub.2                       4-COPh        CH.sub.3                                                                            6-SO.sub.3 Na H    CH.sub.2 OOCC.sub.2 H.sub.5              2,4-di-COOH   CH.sub.3                                                                            6-OCH.sub.2 CH.sub.2 SO.sub.4 K                                                              H    C.sub.6 H.sub.4 -p-OOCCH.sub.3           4-OOCCH.sub.3 CH.sub.3                                                                            6-OCH.sub.2 CH.sub.2 SO.sub.4 K                                                              H    C.sub.6 H.sub.104-CH.sub.3               4-NHCOCH.sub.3                                                                               CH.sub.3                                                                            6-CH.sub.3    H    CH.sub.2 CH.sub.2 (C.sub.4 H.sub.4                                             O.sub.2 N)                               4-NHCOPh      CH.sub.3                                                                            6-Ph          CH.sub.3                                                                            CH.sub.2 CH.sub.2 NO.sub.2               4-C.sub.2 H.sub.5                                                                            CH.sub.3                                                                            6-NO.sub.2    CH.sub.3                                                                            C.sub.6 H.sub.4 -p-NO.sub.2              4-Ph          H    6-OCH.sub.3   CH.sub. 3                                                                           CH.sub.2 NHOCCH.sub.3                    2,5-di-Cl     H    6-NHCOCH.sub.3                                                                               C.sub.2 H.sub.5                                                                     CH.sub.2 NHSO.sub.2 CH.sub.3             2-Cl4-SO.sub.2 CH.sub.3                                                                      H    6-NHSO.sub.2 CH.sub.3                                                                        CH.sub.3                                                                            C.sub.6 H.sub.4 -p-NHOCCH.sub.3          4-NHSO.sub.2 CH.sub.3                                                                        H    6-COOCH.sub.3 CH.sub.3                                                                            C.sub.6 H.sub.4 -p-NHSO.sub.2                                                  CH.sub.3                                 4-COOCH.sub.3 H    6-COOH        H    C.sub.6 H.sub.104-NHOCCH.sub.3           2-OCH.sub.3   C.sub.2 H.sub.5                                                                     6-Cl          CH.sub.3                                                                            CH.sub.2 CH.sub.2 Cl                     4-OC.sub.2 H.sub.5                                                                           C.sub.2 H.sub.5                                                                     5,6-di-Br     C.sub.2 H.sub.5                                                                     C.sub.6 H.sub.4 -p-Br                    4-SO.sub.3 Na C.sub.2 H.sub.5                                                                     5,6-di-Br     H    C.sub.6 H.sub.4 -p-CN                    2-SO.sub.3 Na C.sub.2 H.sub.5                                                                     5-OCH.sub.36-NHCOCH.sub.3                                                                    H    CH.sub.2 CH.sub.2 CN                     2-OCH.sub.34-SO.sub.3 K                                                                      H    6-CH.sub.2 OOCCH.sub.3                                                                       H    CH.sub.2 CH.sub.2 OC.sub.2 H.sub.5       4-OCH.sub.2 CH.sub.2 OSO.sub.3 K                                                             H    6-CH.sub.2 Cl H    CH.sub.2 CH.sub.2 OCH.sub.2                                                    CH.sub.2 OC.sub.2 H.sub.5                2-SO.sub.3 Na5-Cl                                                                            H    6-CN          H    CH.sub.2 Ph                              4-Cl          H    6-OOCCH.sub.3 CH.sub.3                                                                            CH.sub.2 C.sub.6 H.sub.11                4-OH          H    5-COOH        CH.sub.3                                                                            C.sub.6 H.sub.4  -o-OH                   4-CH.sub.2 OOCCH.sub.3                                                                       C.sub.3 H.sub.7n                                                                    5-OH          CH.sub.3                                                                            CH.sub.2 CH.sub.2 OH                     4-SO.sub.3 K  C.sub.3 H.sub.7n                                                                    5-CH.sub.2 CHCH.sub.2                                                                        C.sub.2 H.sub.5                                                                     CH.sub.2 CH.sub.2SO.sub.3 K              4-OPh         H    6-CH.sub.3    CH.sub.3                                                                            C.sub.6 H.sub.4 -p-OSO.sub.3 K           4-NO.sub.2    H    6-COCH.sub.3  CH.sub.3                                                                            CH.sub.2 OPh                             5-CN          H    6-OCH.sub.3   H    CH.sub.2 SO.sub.2 NHPh                   4-COCH.sub.3  H    6-SO.sub.3 Na CH.sub.3                                                                            CH.sub.2 SO.sub.2 NHCH.sub.3             5-CH.sub.3    H    6-OCH.sub.2 CH.sub.2 SO.sub.4 K                                                              H    C.sub.6 H.sub.4 -p-SO.sub.2                                                    NHCH.sub.3                               5-Ph          H    6-OCH.sub.2 CH.sub.2 SO.sub.3 K                                                              H    CH.sub.2 COOCH.sub.3                     5-OCH.sub.3   H    6-CH.sub.3    H    CH.sub.2 SO.sub.2 N(CH.sub.3).sub.2      4,5-di-Br     H    6-Ph          H    C.sub.6 H.sub.4 -p-NHCOOCH.sub.3         5-COOH        C.sub.4 H.sub.9n                                                                    6-NO.sub.2    C.sub.2 H.sub. 5                                                                    CH.sub.2 CH.sub.2 CONH.sub.2             H             H    6-OCH.sub.3   C.sub.2 H.sub.5                                                                     C.sub.6 H.sub.4 -p-CONHCH.sub.3          4-NO.sub.2    H    6-NHCOCH.sub.3                                                                               CH.sub.3                                                                            C.sub.6 H.sub.4 -p-SCH.sub.3             4-CN          H    6-NHSO.sub.2 CH.sub.3                                                                        C.sub.3 H.sub.7n                                                                    CH.sub.2 CH.sub.2 SCH.sub.3              5-COCH.sub.3  H    6-COOCH.sub.3 H    CH.sub.2C.sub.6 H.sub.4 -p-SCH.sub.3     4-COPh        CH.sub.3                                                                            6-COOH        CH.sub.3                                                                            CH.sub.2 SO.sub.2 C.sub.2 H.sub.5        2,4-di-COOH   CH.sub.3                                                                            8-Cl          H    CH.sub.2 SO.sub.2 Ph                     4-OOCCH.sub.3 CH.sub.3                                                                            5,6-di-Br     H    CH.sub.2 CH.sub.2 OSO.sub.3 K            4-NHCOCH.sub.3                                                                               CH.sub.3                                                                            5,6-di-Br     H    C.sub.6 H.sub.4 -p-OSO.sub.3 K           4-NHCOPh      CH.sub.3                                                                            5-OCH.sub.36-NHCOCH.sub.3                                                                    H    CH.sub.2 (C.sub.8 H.sub.4 O.sub.2                                              N)                                       4-CH.sub.2 CHCH.sub.2                                                                        H    6-NHCOCH.sub.3                                                                               C.sub.2 H.sub.5                                                                     C.sub.2 H.sub.5                          H             CH.sub.3                                                                            6-OCPh        C.sub.2 H.sub.5                                                                     C.sub.2 H.sub.5                          4-CONH.sub.2  H    6-CH.sub.2 CONHCH.sub.3                                                                      H    H                                        3-SO.sub.2 NH.sub.2                                                                          H    6-CH.sub.2 CON(CH.sub.3).sub.2                                                               CH.sub.3                                                                            Ph                                       4-SO.sub.2 NHCH.sub.3                                                                        H    6-CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2 OC.sub.2                                H.sub.5       C.sub.2 H.sub.5                                                                     C.sub.6 H.sub.11                         4-SO.sub.2 N(C.sub.2 H.sub.5).sub.2                                                          H    6-CH.sub.2 SC.sub.2 H.sub.5                                                                  H    CH.sub.2CHCH.sub.2                       4-SO.sub.3 C.sub.6 H.sub.5                                                                   CH.sub.3                                                                            6-CH.sub.2 SC.sub.6 H.sub.5                                                                  H    CH.sub.2 OOCC.sub.2 H.sub.5              4-SCH.sub.3   CH.sub.3                                                                            6-CH.sub.2 SO.sub.2 C.sub.2 H.sub.5                                                          H    C.sub.6 H.sub.4 -p-OOCCH.sub.3           2,4-di-SCN    CH.sub.3                                                                            6-CH.sub.2 SO.sub.2 C.sub.6 H.sub.5                                                          H    C.sub.6 H.sub.104-CH.sub.3               4-SO.sub.2 C.sub.6 H.sub.5                                                                   CH.sub.3                                                                            6-C.sub.6 H.sub.3  -o, -p-di-CN                                                              H    CH.sub.2 CH.sub.2(C.sub.4 H.sub.4                                              O.sub.2 N)                               2-CHO4-CN     CH.sub.3                                                                            6-C.sub.6 H.sub.2  -o, .sub.--m, -p-tri-Cl                                                   CH.sub.3                                                                            CH.sub.2 CH.sub.2 NO.sub.2               4-CONHC.sub.2 H.sub.5                                                                        CH.sub.3                                                                            6,8-di-OSO.sub.3 NH(CH.sub.3).sub.3                                                          CH.sub.3                                                                            C.sub.6 H.sub.4 - p-NO.sub.2             4-CON(C.sub.2 H.sub.5).sub.2                                                                 H    5,6-di-OSO.sub.3 Na                                                                          CH.sub.3                                                                            CH.sub.2 NHOCCH.sub.3                    3-C.sub.6 H.sub.11                                                                           H    5,6-di-OSO.sub.3 Na                                                                          C.sub.2 H.sub.5                                                                     CH.sub.2 NHSO.sub.2 CH.sub.3             3-SC.sub.6 H.sub.5                                                                           H    5,6-di-SO.sub.3 NH(CH.sub.3).sub.3                                                           CH.sub.3                                                                            C.sub.6 H.sub.4 -p-NHOCCH.sub.3          4-NHSO.sub.2 C.sub.6 H.sub.5                                                                 H    5,6-di-OSO.sub.3 Na                                                                          CH.sub.3                                                                            C.sub.6 H.sub.4 -p-NHSO.sub.2                                                  CH.sub.3                                 4-SC.sub.6 H.sub.11                                                                          H    6-SC.sub.6 H.sub.11                                                                          H    C.sub.6 H.sub.104-NHOCCH.sub.3           4-C.sub.6 H.sub.4 -p-CH.sub.3                                                                C.sub.2 H.sub.5                                                                     6-C.sub.6 H.sub.4 -p-CH.sub.3                                                                CH.sub.3                                                                            CH.sub.2 CH.sub.2 Cl                     4-C.sub.6 H.sub.4 -p-CH.sub.2 CHCH.sub.2                                                     C.sub.2 H.sub.5                                                                     6-C.sub.6 H.sub.4 -p-CH.sub.2 CHCH.sub.2                                                     C.sub.2 H.sub.5                                                                     C.sub.6 H.sub.4 -p-Br                    4-OCH.sub.2 CH.sub.2 NO.sub.2                                                                C.sub.2 H.sub.5                                                                     6-OCH.sub.2 CH.sub.2 NO.sub.2                                                                H    C.sub.6 H.sub.4  -p-CN                   2-CH.sub.2 NHCOCH.sub.3                                                                      C.sub.2 H.sub.5                                                                     6-CN.sub.2 NHCOCH.sub.3                                                                      H    CH.sub.2 CH.sub.2 CN                     4-CH.sub.2 NHSO.sub.2 C.sub.2 H.sub.5                                                        H    6-CH.sub.2 NHSO.sub.2 C.sub.2 H.sub.5                                                        H    CH.sub.2 CH.sub.2 OC.sub.2 H.sub.5       4-CH.sub.2 CH.sub.2 Cl                                                                       H    6-CH.sub.2 CH.sub.2 Cl                                                                       H    CH.sub.2 CH.sub.2 OCH.sub.2                                                    CH.sub.2 OC.sub.2 H.sub.5                2,6-di-CH.sub.2 CN                                                                           H    5,6-di-CH.sub.2 CN                                                                           H    CH.sub.2 Ph                              4-CH.sub.2 CH.sub.2 OC.sub.2 H.sub.5                                                         H    6-CH.sub.2 CH.sub.2 OC.sub.2 H.sub.5                                                         CH.sub.3                                                                            CH.sub.2 C.sub.6 H.sub.11                4-CH.sub.2 C.sub.6 H.sub.5                                                                   H    6-COOH        CH.sub.3                                                                            C.sub.6 H.sub.4o-OH                      4-CH.sub.2 C.sub.6 H.sub.11                                                                  C.sub.3 H.sub.7n                                                                    6-CH.sub.2 C.sub.6 H.sub.11                                                                  CH.sub.3                                                                            CH.sub.2 CH.sub.2 OH                     4-CH.sub.2 CH(OH)CH.sub.2 OH                                                                 C.sub.3 H.sub.7n                                                                    6-CH.sub.2 CH(OH)CH.sub.2 OH                                                                 C.sub.2 H.sub.5                                                                     CH.sub.2 CH.sub.2SO.sub.3 K              4-CH.sub.2 CH.sub.2SO.sub.3 K                                                                H    6-CH.sub.2 CH.sub.2SO.sub.3 K                                                                CH.sub.3                                                                            C.sub.6 H.sub.4 -p-OSO.sub. 3 K          4-CH.sub.2 OC.sub.6 H.sub.5                                                                  H    6-CH.sub.2 OC.sub.6 H.sub.5                                                                  CH.sub.3                                                                            CH.sub.2 OPh                             4-CH.sub.2 OOCC.sub.6 H.sub.5                                                                H    6-CH.sub.2 OOCC.sub.6 H.sub.5                                                                H    CH.sub.2 SO.sub.2 NHPh                   5-CH.sub.2 COOCH.sub.3                                                                       H    5-CH.sub.2 COOCH.sub.3                                                                       CH.sub.3                                                                            CH.sub.2 SO.sub.2 NHCH.sub.3             4-C.sub.6 H.sub.4 -p-SO.sub.2 N(C.sub.2 H.sub.5).sub.2                                       H    6-C.sub.6 H.sub.4 -p-SO.sub.2 N(C.sub.2 H.sub.5).sub.2                                       H    C.sub.6 H.sub.4 -p-SO.sub.2                                                    NHCH.sub.3                               4-CH.sub.2 CH.sub.2 NHCOOCH.sub.3                                                            H    6-CH.sub.2 CH.sub.2 NHCOOCH.sub.3                                                            H    CH.sub.2 COOCH.sub.3                     4-CH.sub.2 NHCONHCH.sub.3                                                                    H    6-CH.sub.2 NHCONHCH.sub.3                                                                    H    CH.sub.2 SO.sub.2 N(CH.sub.3).sub.2      4-CH.sub.2 CONH.sub.2                                                                        H    6-CH.sub.2 CONH.sub.2                                                                        H    C.sub.6 H.sub.4 -p-NHCOOCH.sub.3         5-CH.sub.2 CONHCH.sub.3                                                                      C.sub.4 H.sub.9n                                                                    6-CONH.sub.2  C.sub.2 H.sub.5                                                                     CH.sub.2 CH.sub.2 CONH.sub.2             4-CH.sub.2 CON(CH.sub.3).sub.2                                                               H    6-SO.sub.2 NH.sub.2                                                                          C.sub.2 H.sub.5                                                                     C.sub.6 H.sub. 4 .sub.-p-CONHCH.sub.                                           3                                        4-CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2 OC.sub.2 H.sub.5                                      H    6-SO.sub.2 NHCH.sub.3                                                                        CH.sub.3                                                                            C.sub.6 H.sub.4 -p-SCH.sub.3             4-CH.sub.2 SC.sub.2 H.sub.5                                                                  H    6-SO.sub.2 N(C.sub.2 H.sub.5).sub.2                                                          C.sub.3 H.sub.7n                                                                    CH.sub.2 CH.sub.2 SCH.sub.3              5-CH.sub.2 SC.sub.6 H.sub.5                                                                  H    6-SO.sub.3 C.sub.6 H.sub.5                                                                   H    CH.sub.2C.sub.6 H.sub.4p-SCH.sub.3       4-CH.sub.2 SO.sub.2 C.sub.2 H.sub.5                                                          CH.sub.3                                                                            6-SCH.sub.3   CH.sub.3                                                                            CH.sub.2 SO.sub.2 C.sub.2 H.sub.5        2,4-di-CH.sub.2 SO.sub.2 C.sub.6 H.sub.5                                                     CH.sub.3                                                                            5,6-di-SCN    H    CH.sub.2 SO.sub.2 Ph                     4-C.sub.6 H.sub.3  -o, -p-di-CN                                                              CH.sub.3                                                                            6-SO.sub.2 C.sub.6 H.sub.5                                                                   H    CH.sub.2 CH.sub.2 OSO.sub.3 K            4-C.sub.6 H.sub.2  -o, .sub.--m, -p-tri-Cl                                                   CH.sub.3                                                                            5-CHO6-CN     H    C.sub.6 H.sub.4 -p-OSO.sub.3 K           2,6-di-OSO.sub.3 Na                                                                          CH.sub.3                                                                            6-CONHC.sub.2 H.sub. 5                                                                       H    CH.sub.2(C.sub.8 H.sub.4 O.sub.2                                               N)                                       H             H    6-CON(C.sub.2 H.sub.5).sub.2                                                                 H    C.sub.2 H.sub.5                          H             H    6-C.sub.6 H.sub.11                                                                           H    C.sub.2 H.sub.5                          5-CH.sub.2 (C.sub.8 H.sub.4 O.sub.2 N)                                                       H    6-SC.sub.6 H.sub.5                                                                           H    C.sub.2 H.sub.5                          5-CH.sub.2 (C.sub.4 H.sub.3 O)                                                               H    6-NHSO.sub.2 C.sub.6 H.sub.5                                                                 H    C.sub.2 H.sub.5                          __________________________________________________________________________

    TABLE 4       ##STR12##        Cinnamoyl Group Position R.sub.1 on D R.sub.5 Substituents on E      R.sub.1 on C R.sub.2 R.sub.7        4 H H H H H H 4 4-NO.sub.2 H COCH.sub.3 2-CH.sub.3 C.sub.2 H.sub.5 Ph      4 4-CN H NO.sub.2 5-COCH.sub.3 C.sub.2 H.sub.5 C.sub.6 H.sub.11 4      5-COCH.sub.3 H Cl 5-OCH.sub.3 H CH.sub.2CHCH.sub.2 4 4-COPh CH.sub.3 CN      5-SO.sub.3 Na H CH.sub.2 OOCC.sub.2 H.sub.5 4 2,4-di-COOH CH.sub.3      NHSO.sub.2 CH.sub.3 5-OCH.sub.2 CH.sub.2 SO.sub.4 K H C.sub.6       H.sub.4p-OOCCH.sub.3 4 4-OOCCH.sub.3 CH.sub.3 CH.sub.3 5-OCH.sub.2      CH.sub.2 SO.sub.4 N H(Et).sub.3 H C.sub.6 H.sub.104-CH.sub.3 3,4      4-NHCOCH.sub.3 CH.sub.3  2-CH.sub.3 H CH.sub.2 CH.sub.2 (C.sub.4 H.sub.4      O.sub.2 N) 3 4-NHCOPh CH.sub.3 Ph 2-Ph CH.sub.3 CH.sub.2 CH.sub.2      NO.sub.2 4 4-C.sub.2 H.sub.5 CH.sub.3 H 2-NO.sub.2 CH.sub.3 C.sub.6      H.sub.4p-NO.sub.2 3 4-Ph H H 2-OCH.sub.3 CH.sub.3 CH.sub.2 NHOCCH.sub.3      4 2,5-di-Cl H SO.sub.3 Na 5-NHCOCH.sub.3 C.sub.2 H.sub.5 CH.sub.2      NHSO.sub.2 CH.sub.3 4 2-Cl4-SO.sub.2 CH.sub.3 H SO.sub.3 Na 3-NHSO.sub.2      CH.sub.3 C.sub.2 H.sub.5 C.sub.6 H.sub.4p-NHOCCH.sub.3 4 4-NHSO.sub.2      CH.sub.3 H OCH.sub.2 CH.sub.2 SO.sub.4 K 3-COOCH.sub.3 C.sub.2 H.sub.5      C.sub.6 H.sub.4p-NHSO.sub.2 CH.sub.3 4 4-COOCH.sub.3 H OCH.sub.2      CH.sub.2 SO.sub.4 K 3-COOH C.sub.2 H.sub.5 C.sub.6       H.sub.104-NHOOCH.sub.3 4 2-OCH.sub.3 C.sub.2 H.sub.5 NHCOPh 2-Cl      CH.sub.2 CH.sub.2 Cl CH.sub.2 CH.sub.2 Cl 4 4-OC.sub.2 H.sub.5 C.sub.2      H.sub.5 NHCOPh 2,6-di-Br C.sub.6 H.sub.4p-Br C.sub.6 H.sub.4p-Br 4      4-SO.sub.3 Na C.sub.2 H.sub.5 NHCOCH.sub.3 2,6-di-Br C.sub.6 H.sub.4p-CN      C.sub.6 H.sub.4p-CN 4 2-SO.sub.3 Na C.sub.2 H.sub.5 OOCC.sub.2 H.sub.5      2-OCH.sub.35-NHCOCH.sub.3 CH.sub.2 CH.sub.2 CN CH.sub.2 CH.sub.2 CN 4      2-OCH.sub.34-SO.sub.3 K H COOH 2-CH.sub.2 OOCCH.sub.3 CH.sub.2 CH.sub.2      OC.sub.2 H.sub.5 CH.sub.2 CH.sub.2 OC.sub.2 H.sub.5 4 4-OCH.sub.2      CH.sub.2 OSO.sub.3 K H H 2-CH.sub.2 Cl CH.sub.2 CH.sub.2 OCH.sub.2      CH.sub.2 OC.sub.2 H.sub.5 CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2 OC.sub.2      H.sub.5 4 2-SO.sub.3 Na5-Cl H H 2-CN CH.sub.2 Ph CH.sub.2 Ph 4 4-Cl H      SO.sub.2 CH.sub.3 2-OOCCH.sub.3 CH.sub.2 C.sub.6 H.sub.11 CH.sub.2      C.sub.6 H.sub.11 4 4-OH H CF.sub.3 5-COOH H C.sub.6 H.sub.4o-OH 4      4-CH.sub.2 OOCCH.sub.3 C.sub.3 H.sub.7n COOCH.sub.3 5-OH C.sub.2 H.sub.5      CH.sub.2 CH.sub.2 OH 3,4 4-SO.sub.3 K C.sub.3 H.sub.7n  5-CH.sub.2      CHCH.sub.2 CH.sub.2 CH.sub.2SO.sub.3 K CH.sub.2 CH.sub.2SO.sub.3 K 3      4-OPh H CONH.sub.2 2-CH.sub.3 H C.sub.6 H.sub.4p-OSO.sub.3       K 4 4-NO.sub.2 H CONHCH.sub.3 5-COCH.sub.3 H CH.sub.2 OPh 4 5-CN H      CH.sub.2 Ph 5-OCH.sub.3 H CH.sub.2 SO.sub.2 NHPh 4 4-COCH.sub.3 H      CH.sub.2 SO.sub.3 K 5-SO.sub.3 Na CH.sub.2 SO.sub.2 NHCH.sub.3 CH.sub.2      SO.sub.2 NHCH.sub.3 4 5-CH.sub.3 H CH.sub.2 OSO.sub.3 K 5-OCH.sub.2      CH.sub.2 SO.sub.4 K H C.sub.6 H.sub.4p-SO.sub.2 NHCH.sub.3 4 5-Ph H      C.sub.6 H.sub.4p-SO.sub.3 K 5-OCH.sub.2 CH.sub.2 SO.sub.3 K CH.sub.2      COOCH.sub.3 CH.sub.2 COOCH.sub.3 4 5-OCH.sub.3 H CH.sub.2 CH.sub.2 OH      2-CH.sub.3 H CH.sub.2 SO.sub.2 N(CH.sub.3).sub.2 4 4,5-di-Br H CH.sub.2      Cl 2-Ph C.sub.2 H.sub.5 C.sub.6 H.sub.4p-NHCOOCH.sub.3 4 5-COOH C.sub.4      H.sub.9n C.sub.6 H.sub.4p-Br 2-NO.sub.2 C.sub.2 H.sub.5 CH.sub.2      CH.sub.2 CONH.sub.2 4 H H H 2-OCH.sub.3 C.sub.2 H.sub.5 C.sub.6       H.sub.4p-CONHCH.sub.3 4 4-NO.sub.2 H COCH.sub.3 5-NHCOCH.sub.3 C.sub.2      H.sub.5 C.sub.6 H.sub.4p-SCH.sub.3 4 4-CN H NO.sub.2 3-NHSO.sub.2      CH.sub.3 CH.sub.2 CH.sub.2 SCH.sub.3 CH.sub.2 CH.sub.2 SCH.sub.3 4      5-COCH.sub.3 H Cl 3-COOCH.sub.3 H CH.sub.2C.sub.6 H.sub.4p-SCH.sub.3 4      4-COPh CH.sub.3 CN 3-COOH CH.sub.2 SO.sub.2 C.sub.2 H.sub.5 CH.sub.2      SO.sub.2 C.sub.2 H.sub.5 4 2,4-di-COOH CH.sub.3 NHSO.sub.2 CH.sub.3 2-Cl      H CH.sub.2 SO.sub.2 Ph 4 4-OOCCH.sub.3 CH.sub.3 CH.sub.3 2,6-di-Br H      CH.sub.2 CH.sub.2 OSO.sub.3 K 4 4-NHCOCH.sub.3 CH.sub.3 OCH.sub.3      2,6-di-Br H C.sub.6 H.sub.4p-OSO.sub.3       K 4 4-NHCOPh CH.sub.3 Ph 2-OCH.sub.35-NHCOCH.sub.3 H CH.sub.2 (C.sub.8      H.sub.4 O.sub.2 N) 4 4-CH.sub.2 CHCH.sub.2 H H 3-NHCOCH.sub. 3 C.sub.2      H.sub.5 C.sub.2 H.sub.5 3,4 H CH.sub.3  3-OCPh C.sub.2 H.sub.5 C.sub.2      H.sub.5 3 4-CONH.sub.2 H H 5-CH.sub.2 CONHCH.sub.3 H H 3 3-SO.sub.2      NH.sub.2 H COCH.sub.3 5-CH.sub.2 CON(CH.sub.3).sub.2 C.sub.2 H.sub.5 Ph      3 4-SO.sub.2 NHCH.sub.3 H NO.sub.2 5-CH.sub.2 CH.sub.2 OCH.sub.2      CH.sub.2 OC.sub.2 H.sub.5 C.sub.2 H.sub.4 C.sub.6 H.sub.11 3 4-SO.sub.2      N(C.sub.2 H.sub.5).sub.2 H Cl 5-CH.sub.2 SC.sub.2       H.sub.5 H CH.sub.2CHCH.sub.2 3 4-SO.sub.3 C.sub.6 H.sub.5 CH.sub.3 CN      2-CH.sub.2 SC.sub.6 H.sub.5 H CH.sub.2 OOCC.sub.2 H.sub.5 3 4-SCH.sub.3      CH.sub.3 NHSO.sub.2 CH.sub.3 5-CH.sub.2 SO.sub.2 C.sub.2 H.sub.5 H      C.sub.6 H.sub.4p-OOCCH.sub.3 4 2,4-di-SCN CH.sub.3 CH.sub.3 5-CH.sub.2      SO.sub.2 C.sub.6 H.sub.5 H C.sub.6 H.sub.104-CH.sub.3 4 4-SO.sub.2      C.sub.6 H.sub.5 CH.sub.3 OCH.sub.3 5-C.sub.6 H.sub.3o,p-di-CN H CH.sub.2      CH.sub.2 (C.sub.4 H.sub.4 O.sub.2 N) 4 2-CHO-4-CN CH.sub.3 Ph 5-C.sub.6      H.sub.2o,m,p-tri-Cl CH.sub.3 CH.sub.2 CH.sub.2 NO.sub.2 4 4-CONHC.sub.2      H.sub.5 CH.sub.3 H 2,6-di-OSO.sub.3 N H(CH.sub.3).sub.3 CH.sub.3 C.sub.6      H.sub.4p-NO.sub.2 4 4-CON(C.sub.2 H.sub.5).sub.2 H H 2,6-di-SO.sub.3 N      H(CH.sub.3).sub.3 CH.sub.3 CH.sub.2 NHOCCH.sub.3 4 3-C.sub.6 H.sub.11 H      SO.sub.3 Na 2,6-di-OSO.sub.3 K C.sub.2 H.sub.5 CH.sub.2 NHSO.sub.2      CH.sub.3 4 3-SC.sub.6 H.sub.5 H SO.sub.3 Na 2-SO.sub.3       N H(CH.sub.3).sub.3 C.sub.2 H.sub.5 C.sub.6 H.sub.4p-NHOCCH.sub.3 4      4-NHSO.sub.2 C.sub.6 H.sub.5 H OCH.sub.2 CH.sub.2 SO.sub.4 K 2-OSO.sub.3      N H(CH.sub.3).sub.3 C.sub.2 H.sub.5 C.sub.6 H.sub.4p-NHSO.sub.2 CH.sub.3      4 4-SC.sub.6 H.sub.11 H OCH.sub.2 CH.sub.2 SO.sub.4 K 5-SC.sub.6      H.sub.11 C.sub.2 H.sub.5 C.sub.6 H.sub.104-NHOCCH.sub.3 4 4-C.sub.6      H.sub.4p-CH.sub.3 C.sub.2 H.sub.5 NHCOPh 5-C.sub.6 H.sub.4p-CH.sub.3      CH.sub.2 CH.sub.2 Cl CH.sub.2 CH.sub.2 Cl 4 4-C.sub.6 H.sub.4p-CH.sub.2      CHCH.sub.2 C.sub.2 H.sub.5 NHCOPh 5-C.sub.6 H.sub.4p-CH.sub.2 CHCH.sub.2      C.sub.6 H.sub.4p-Br C.sub.6 H.sub.4p-Br 4 4-OCH.sub.2 CH.sub.2 NO.sub.2      C.sub.2 H.sub.5 NHCOCH.sub.3 5-OCH.sub.2 CH.sub.2 NO.sub.2 C.sub.6      H.sub.4p-CN C.sub.6 H.sub.4p-CN 4 2-CH.sub.2 NHCOCH.sub.3 C.sub.2      H.sub.5 OOCC.sub.2 H.sub.5 2-CH.sub.2 NHCOCH.sub.3 CH.sub.2 CH.sub.2 CN      CH.sub.2 CH.sub.2 CN 4 4-CH.sub.2 NHSO.sub.2 C.sub.2 H.sub.5 H COOH      5-CH.sub.2 NHSO.sub.2 C.sub.2 H.sub.5 CH.sub.2 CH.sub.2 OC.sub.2 H.sub.5      CH.sub.2 CH.sub.2 OC.sub.2 H.sub.5 4 4-CH.sub.2 CH.sub.2       Cl H H 5-CH.sub.2 CH.sub.2 Cl CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2      OC.sub.2 H.sub.5 CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2 OC.sub.2 H.sub.5 4      2,6-di-CH.sub.2 CN H H 2,6-di-CH.sub.2 CN CH.sub.2 Ph CH.sub.2 Ph 4      4-CH.sub.2 CH.sub.2 OC.sub.2 H.sub.5 H SO.sub.2 CH.sub.3 5-CH.sub.2      CH.sub.2 OC.sub.2 H.sub.5 CH.sub.2 C.sub.6 H.sub.11 CH.sub.2 C.sub.6      H.sub.11 4 4-CH.sub.2 C.sub.6 H.sub.5 H CH.sub.2 C.sub.6 H.sub.5 5-COOH      H C.sub.6 H.sub.4o-OH 4 4-CH.sub.2 C.sub.6 H.sub.11 C.sub.3 H.sub.7n      COOCH.sub.3 5-CH.sub.2 C.sub.6 H.sub.11 C.sub.2 H.sub.5 CH.sub.2      CH.sub.2 OH 4 4-CH.sub.2 CH(OH)CH.sub.2 OH C.sub.3       H.sub.7n CHO 5-CH.sub.2 CH(OH)CH.sub.2 OH CH.sub.2 CH.sub.2SO.sub.3 K      CH.sub.2 CH.sub.2SO.sub.3 K 4 4-CH.sub.2 CH.sub.2SO.sub.3 K H CONH.sub.2      5-CH.sub.2 CH.sub.2SO.sub.3 K H C.sub.6 H.sub.4p-OSO.sub.3       K 4 4-CH.sub.2 OC.sub.6 H.sub.5 H CONHCH.sub.3 5-CH.sub.2 OC.sub.6      H.sub.5 H CH.sub.2 OPh 4 4-CH.sub.2 OOCC.sub.6 H.sub.5 H CH.sub.2 Ph      5-CH.sub.2 OOCC.sub.6 H.sub.5 H CH.sub.2 SO.sub.2 NHPh 4 5-CH.sub.2      COOCH.sub.3 H CH.sub.2 SO.sub.3 K 5-CH.sub.2 COOCH.sub.3 CH.sub.2      SO.sub.2 NHCH.sub.3 CH.sub.2 SO.sub.2 NHCH.sub.3 4 4-C.sub.6       H.sub.4p-SO.sub.2 N(C.sub.2 H.sub. 5).sub.2 H CH.sub.2 OSO.sub.3 K      5-C.sub.6 H.sub.4p-SO.sub.2 N(C.sub.2 H.sub.5).sub.2 H C.sub.6       H.sub.4p-SO.sub.2 NHCH.sub.3 4 4-CH.sub.2 CH.sub.2 NHCOOCH.sub.3 H      C.sub.6 H.sub.4p-SO.sub.3 K 5-CH.sub.2 CH.sub.2 NHCOOCH.sub.3 CH.sub.2      COOCH.sub.3 CH.sub.2 COOCH.sub.3 3 4-CH.sub.2 NHCONHCH.sub.3 H CH.sub.2      CH.sub.2 OH 5-CH.sub.2 NHCONHCH.sub.3 H CH.sub.2 SO.sub.2       N(CH.sub.3).sub.2 3 4-CH.sub.2 CONH.sub.2 H CH.sub.2 Cl 5-CH.sub.2      CONH.sub.2 C.sub.2 H.sub.5 C.sub.6 H.sub.4p-NHCOOCH.sub.3 3 5-CH.sub.2      CONHCH.sub.3 C.sub.4 H.sub.9n C.sub.6 H.sub.4p-Br 5-CONH.sub.2 C.sub.2      H.sub.5 CH.sub.2 CH.sub.2 CONH.sub.2 3 4-CH.sub.2 CON(CH.sub.3).sub.2 H      H 3-SO.sub.2 NH.sub.2 C.sub.2 H.sub.5 C.sub.6 H.sub.4p-CONHCH.sub.3 3      4-CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2 OC.sub.2 H.sub.5 H COCH.sub.3      5-SO.sub.2 NHCH.sub.2 C.sub.6 H.sub.5 C.sub.6 H.sub.4p-SCH.sub.3 3,4      4-CH.sub.2 SC.sub.2 H.sub.5 H  5-SO.sub.2 N(C.sub.2 H.sub. 5).sub.2      CH.sub.2 CH.sub.2 SCH.sub.3 CH.sub.2 CH.sub.2 SCH.sub.3 4 5-CH.sub.2      SC.sub.6 H.sub.5 H Cl 5-SO.sub.3 C.sub.6 H.sub.5 H CH.sub.2C.sub.6      H.sub.4p-SCH.sub.3 4 4-CH.sub.2 SO.sub.2 C.sub.2 H.sub.5 CH.sub.3 CN      5-SCH.sub.3 CH.sub.2 SO.sub.2 C.sub.2 H.sub.5 CH.sub.2 SO.sub.2 C.sub.2      H.sub.5 4 2,4-di-CH.sub.2 SO.sub.2 C.sub.6 H.sub.5 CH.sub.3 NHSO.sub.2      CH.sub.3 2,5-di-SCN H CH.sub.2 SO.sub.2 Ph 4 4-C.sub.6 H.sub.3o,p-di-CN      CH.sub.3 CH.sub.3 5-SO.sub.2 C.sub.6 H.sub.5 H CH.sub.2 CH.sub.2      OSO.sub.3 K 4 4-C.sub.6 H.sub.2o,m,p-tri-Cl CH.sub.3 OCH.sub.3 2-CHO6-CN      H C.sub.6 H.sub.4p-OSO.sub.3 K 4 2,6-di-OSO.sub.3 Na CH.sub.3 Ph      5-CONHC.sub.2 H.sub.5 H CH.sub.2(C.sub.8 H.sub.4 O.sub.2 N) 4 H H      CH.sub.2 (C.sub.4 H.sub.4 O.sub.2 N) 5-CON(C.sub.2 H.sub.5).sub.2      C.sub.2 H.sub.5 C.sub.2 H.sub.5 4 H H CH.sub.2 (C.sub.4 H.sub.3 O)      3-C.sub.6 H.sub.11 C.sub.2 H.sub.5 C.sub.2 H.sub.5 4 5-CH.sub.2 (C.sub.8      H.sub.4 O.sub.2 N) H H 3-SC.sub.6 H.sub.5 C.sub.2 H.sub.5 C.sub.2      H.sub.5 4 5-CH.sub.2 (C.sub.4 H.sub.3 O) H H 6-NHSO.sub.2 C.sub.6      H.sub.5 C.sub.2 H.sub.5 C.sub.2       H.sub.5

    TABLE 5       ##STR13##        Cinnamoyl Group Position R.sub.1 on D R.sub.5 Substituents on E      R.sub.1 on C R.sub.3 R.sub.4 R.sub.8 R.sub.7        4 H H H H H H H H 4 4-NO.sub.2 H COCH.sub.3 7-CH.sub.3 CH.sub.3      CH.sub.3 CH.sub.3 Ph 4 4-CN H NO.sub.2 5-COCH.sub.3 CH.sub.3 CH.sub.3 H      C.sub.6 H.sub.11 4 5-COCH.sub.3 H Cl 5-OCH.sub.3 CH.sub.3 CH.sub.3 H      CH.sub.2CHCH.sub.2 4 4-COPh CH.sub.3 CN 7-SO.sub.3 Na CH.sub.3 CH.sub.3      H CH.sub.2 OOCC.sub.2 H.sub.5 4 2,4-di-COOH CH.sub.3 NHSO.sub.2 CH.sub.3      7-OCH.sub.2 CH.sub.2 SO.sub.4 K CH.sub.3 CH.sub.3 H C.sub.6       H.sub.4-p-OOCCH.sub.3 4 4-OOCCH.sub.3 CH.sub.3 CH.sub.3 7-OCH.sub.2      CH.sub.2 SO.sub.4 NH(Et).sub.3 CH.sub.3 CH.sub.3 H C.sub.6       H.sub.104-CH.sub.3 3,4 4-NHCOCH.sub.3 CH.sub.3  7-CH.sub.3 CH.sub.3 H H      CH.sub.2 CH.sub.2 (C.sub.4 H.sub.4 O.sub.2 N) 3 4-NHCOPh CH.sub.3 Ph      7-Ph CH.sub.3 H H CH.sub.2 CH.sub.2 NO.sub.2 3 4-C.sub.2 H.sub.5      CH.sub.3 H 7-NO.sub.2 CH.sub.3 H H C.sub.6 H.sub.4-p-NO.sub.2 3 4-Ph H H      7-OCH.sub.3 CH.sub.3 H H CH.sub.2 NHOCCH.sub.3 4 2,5-di-Cl H SO.sub.3 Na      7-NHCOCH.sub.3 CH.sub.3 H H CH.sub.2 NHSO.sub. 2       CH.sub.3 4 2-Cl4-SO.sub.2 CH.sub.3 H SO.sub.3 Na 7-NHSO.sub.2 CH.sub.3      CH.sub.3 H H C.sub.6 H.sub.4-p-NHOCCH.sub.3 4 4-NHSO.sub.2 CH.sub.3 H      OCH.sub.2 CH.sub.2 SO.sub.4 K 7-COOCH.sub.3 CH.sub.3 C.sub.2 H.sub.5      C.sub.2 H.sub.5 C.sub.6 H.sub.4-p-NHSO.sub.2 CH.sub.3 4 4-COOCH.sub.3 H      OCH.sub.2 CH.sub.2 SO.sub.4 K 7-COOH H H H C.sub.6       H.sub.104-NHOCCH.sub.3 4 2-OCH.sub.3 C.sub.2 H.sub.5 NHCOPh 7-Cl      CH.sub.3 CH.sub.3 CH.sub.3 CH.sub.2 CH.sub.2 Cl 4 4-OC.sub.2 H.sub.5      C.sub.2 H.sub.5 NHCOPh 5,7-di-Br CH.sub.3 CH.sub.3 H C.sub.6       H.sub.4-p-Br 4 4-SO.sub.3 Na C.sub.2 H.sub.5 NHCOCH.sub.3 5,7-di-Br      CH.sub.3 CH.sub.3 H C.sub.6 H.sub.4-p-CN 4 2-SO.sub.3 Na C.sub.2 H.sub.5      OOCC.sub.2 H.sub.5 5-OCH.sub.37-NHCOCH.sub.3 CH.sub.3 CH.sub.3 H      CH.sub.2 CH.sub.2 CN 4 2-OCH.sub.34-SO.sub.3 K H COOH 7-CH.sub.2      OOCCH.sub. 3 CH.sub.3 CH.sub.3 H CH.sub.2 CH.sub.2 OC.sub.2 H.sub.5 4      4-OCH.sub.2 CH.sub.2 OSO.sub.3 K H H 7-CH.sub.2 Cl CH.sub.3 CH.sub.3 H      CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2 OC.sub.2 H.sub.5 4 2-SO.sub.3      Na5-Cl H H 7-CN CH.sub.3 H H CH.sub.2 Ph 4 4-Cl H SO.sub.2 CH.sub.3      7-OOCCH.sub.3 CH.sub.3 H H CH.sub.2 C.sub.6 H.sub.11 4 4-OH H CF.sub.3      5-COOH CH.sub.3 H H C.sub.6 H.sub.4.sub.-o-OH 4 4-CH.sub.2 OOCCH.sub.3      C.sub.3 H.sub.7n COOCH.sub.3 5-OH CH.sub.3 H H CH.sub.2 CH.sub.2 OH 3,4      4-SO.sub.3 K C.sub.3 H.sub.7n  5-CH.sub.2 CHCH.sub.2 CH.sub.3 H H      CH.sub.2 CH.sub.2SO.sub.3 K 3 4-OPh H CONH.sub.2 7-CH.sub.3 CH.sub.3 H H      C.sub.6 H.sub.4-p-OSO.sub.3 K 4 4-NO.sub.2 H CONHCH.sub.3 7-COCH.sub.3      CH.sub.3 C.sub.2 H.sub.5 C.sub.2 H.sub.5 CH.sub.2 OPh 4 5-CN H CH.sub.2      Ph 7-OCH.sub.3 H H H CH.sub.2 SO.sub.2 NHPh 4 4-COCH.sub.3 H CH.sub.2      SO.sub.3 K 7-SO.sub.3 Na CH.sub.3 CH.sub.3 CH.sub.3 CH.sub.2 SO.sub.2      NHCH.sub.3 4 5-CH.sub.3 H CH.sub.2 OSO.sub.3 K 7-OCH.sub.2 CH.sub.2      SO.sub.4 K CH.sub.3 CH.sub.3 H C.sub.6 H.sub.4-p-SO.sub.2 NHCH.sub.3 4      5-Ph H C.sub.6 H.sub.4p-SO.sub.3 K 7-OCH.sub.2 CH.sub.2 SO.sub.3 K      CH.sub.3 CH.sub.3 H CH.sub.2 COOCH.sub.3 4 5-OCH.sub.3 H CH.sub.2      CH.sub.2 OH 7-CH.sub.3 CH.sub.3 CH.sub.3 H CH.sub.2 SO.sub.2       N(CH.sub.3).sub.2 4 4,5-di-Br H CH.sub.2 Cl 7-Ph CH.sub.3 CH.sub.3 H      C.sub.6 H.sub.4-p-NHCOOCH.sub.3 4 5-COOH C.sub.4 H.sub.9n C.sub.6      H.sub.4-p-Br 7-NO.sub.2 H H H CH.sub.2 CH.sub.2 CONH.sub.2 4 H H H      7-OCH.sub.3 CH.sub.3 CH.sub.3 CH.sub.3 C.sub.6 H.sub.4-p-CONHCH.sub.3 4      4-NO.sub.2 H COCH.sub.3 7-NHCOCH.sub.3 CH.sub.3 CH.sub.3 H C.sub.6      H.sub.4- p-SCH.sub.3 4 4-CN H NO.sub.2 7-NHSO.sub.2 CH.sub.3 CH.sub.3      CH.sub.3 H CH.sub.2 CH.sub.2 SCH.sub.3 4 5-COCH.sub.3 H Cl 7-COOCH.sub.3      CH.sub.3 CH.sub.3 H CH.sub.2C.sub.6 H.sub.4-p-SCH.sub.3 4 COPh CH.sub.3      CN 7-COOH CH.sub.3 CH.sub.3 H CH.sub.2 SO.sub.2 C.sub.2 H.sub.5 4      2,4-di-COOH CH.sub.3 NHSO.sub.2 CH.sub.3 7-Cl CH.sub.3 CH.sub.3 H      CH.sub.2 SO.sub.2 Ph 4 4-OOCCH.sub.3 CH.sub.3 CH.sub.3 5,7-di-Br      CH.sub.3 H H CH.sub.2 CH.sub.2 OSO.sub.3 K 4 4-NHCOCH.sub.3 CH.sub.3      OCH.sub.3 5,7-di-Br CH.sub.3 H H C.sub.6 H.sub.4-p-OSO.sub.3 K 4      4-NHCOPh CH.sub.3 Ph 5-OCH.sub.37-NHCOCH.sub.3 CH.sub.3 H H CH.sub.2      (C.sub.8 H.sub.4 O.sub.2 N) 4 4-CH.sub.2 CHCH.sub.2 H H 7-NHCOCH.sub.3      C.sub.2 H.sub.5 H H C.sub.2 H.sub.5 3,4 H CH.sub.3 -- 7-OCPh C.sub.2      H.sub.5 H H C.sub.2 H.sub.5 3 4-CONH.sub.2 H H 7-CH.sub.2 CONHCH.sub.3 H      H H H 3 3-SO.sub.2 NH.sub.2 H COCH.sub.3 7-CH.sub.3 CON(CH.sub.3).sub.2      CH.sub.3 CH.sub.3 CH.sub.3 Ph 3 4-SO.sub.2 NHCH.sub.3 H NO.sub.2      7-CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2 OC.sub.2 H.sub.5 CH.sub.3      CH.sub.3 H C.sub.6 H.sub.11 3 4-SO.sub.2 N(C.sub.2 H.sub.5).sub.2 H Cl      7-CH.sub.2 SC.sub.2 H.sub.5 CH.sub.3 CH.sub.3 H CH.sub.2CHCH.sub.2 3      4-SO.sub.3 C.sub.6 H.sub.5 CH.sub.3 CN 7-CH.sub.2 SC.sub.6 H.sub.5      CH.sub.3 CH.sub.3 H CH.sub.2 OOCC.sub.2 H.sub.5 3 4-SCH.sub.3 CH.sub.3      NHSO.sub.2 CH.sub.3 7-CH.sub.2 SO.sub.2 C.sub.2 H.sub.5 CH.sub.3      CH.sub.3 H C.sub.6 H.sub.4-p-OOCCH.sub.3 4 2,4-di-SCN CH.sub.3 CH.sub.3      7-CH.sub.2 SO.sub.2 C.sub.6 H.sub.5 CH.sub.3 CH.sub.3 H C.sub.6       H.sub.104-CH.sub.3 4 4-SO.sub.2 C.sub.6 H.sub.5 CH.sub.3 OCH.sub.3      7-C.sub.6 H.sub.3.sub.-o-,-p-di-CN CH.sub.3 H H CH.sub.2       CH.sub.2(C.sub.4 H.sub.4 O.sub.2 N) 4 2-CHO4-CN CH.sub.3 Ph 7-C.sub.6      H.sub.2.sub.-o,--m,-p-tri-Cl CH.sub.3 H H CH.sub.2 CH.sub.2 NO.sub.2 4      4-CONHC.sub.2 H.sub.5 CH.sub.3 H 5,7-di-OSO.sub.3 NH(CH.sub.3).sub.3      CH.sub.3 H H C.sub.6 H.sub.4-p-NO.sub.2 4 4-CON(C.sub.2 H.sub.5).sub.2 H      H 5,7-di-OSO.sub.3 Na CH.sub.3 H H CH.sub.2 NHOCCH.sub.3 4 3-C.sub.6      H.sub.11 H SO.sub.3 Na 5,7-di-SO.sub.3 NH(CH.sub.3).sub.3 CH.sub.3 H H      CH.sub.2 NHSO.sub.2 CH.sub.3 4 3-SC.sub.6 H.sub.5 H SO.sub.3       Na 7-OSO.sub.3 NH(CH.sub.3).sub.3 CH.sub.3 H H C.sub.6       H.sub.4-p-NHOCCH.sub.3 4 4-NHSO.sub.2 C.sub.6 H.sub.5 H OCH.sub.2      CH.sub.2 SO.sub.4 K 5,7-di-OSO.sub.3 Na CH.sub.3 C.sub.2 H.sub.5 C.sub.2      H.sub.5 C.sub.6 H.sub.4-p-NHSO.sub.2 CH.sub.3 4 4-SC.sub.6 H.sub.11 H      OCH.sub.2 CH.sub.2 SO.sub.4 K 7-SC.sub.6 H.sub. 11 H H H C.sub.6         4      H.sub.10-NHOCCH.sub.3 4 4-C.sub.6 H.sub.4-p-CH.sub.3 C.sub.2 H.sub.5      NHCOPh 7-C.sub.6 H.sub.4-p-CH.sub.3 CH.sub.3 CH.sub.3 CH.sub.3 CH.sub.2      CH.sub.2 Cl 4 4-C.sub.6 H.sub.4-p-CH.sub.2 CHCH.sub.2 C.sub.2 H.sub.5      NHCOPh 7-C.sub.6 H.sub.4-p-CH.sub.2 CHCH.sub.2 CH.sub.3 CH.sub.3 H      C.sub.6 H.sub.4-p-Br 4 4-OCH.sub.2 CH.sub.2 NO.sub.2 C.sub.2 H.sub.5      NHCOCH.sub.3 7-OCH.sub.2 CH.sub.2 NO.sub.2 CH.sub.3 CH.sub.3 H C.sub.6      H.sub.4-p-CN 4 2-CH.sub.2 NHCOCH.sub.3 C.sub.2 H.sub.5 OOCC.sub.2      H.sub.5 7-CH.sub.2 NHCOCH.sub.3 CH.sub.3 CH.sub.3 H CH.sub.2 CH.sub.2 CN      4 4-CH.sub.2 NHSO.sub.2 C.sub.2 H.sub.5 H COOH 7-CH.sub.2 NHSO.sub.2      C.sub.2 H.sub.5 CH.sub.3 CH.sub.3 H CH.sub.2 CH.sub.2 OC.sub.2 H.sub.5 4      4-CH.sub.2 CH.sub.2 Cl H H 7-CH.sub.2 CH.sub.2 Cl CH.sub.3 CH.sub.3 H      CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2 OC.sub.2 H.sub.5 4 2,6-di-CH.sub.2      CN H H 5,7-di-CH.sub.2 CN CH.sub.3 H H CH.sub.2 Ph 4 4-CH.sub.2 CH.sub.2      OC.sub.2 H.sub.5 H SO.sub.2 CH.sub.3 7-CH.sub.2 CH.sub.2 OC.sub.2      H.sub.5 CH.sub.3 H H CH.sub.2 C.sub.6 H.sub.11 4 4-CH.sub.2 C.sub.6      H.sub.5 H CH.sub.2 C.sub.6 H.sub.5 7-COOH CH.sub.3 H H C.sub.6       H.sub.4.sub.-o-OH 4 4-CH.sub.2 C.sub.6 H.sub.11 C.sub.3 H.sub.7n      COOCH.sub.3 7-CH.sub.2 C.sub.6 H.sub.11 CH.sub.3 H H CH.sub.2 CH.sub.2      OH 4 4-CH.sub.2 CH(OH)CH.sub.2 OH C.sub.3 H.sub.7n CHO 7-CH.sub.2      CH(OH)CH.sub.2 OH CH.sub.3 H H CH.sub.2 CH.sub.2SO.sub.3 K 4 4-CH.sub.2      CH.sub.2SO.sub.3 K H CONH.sub.2 7-CH.sub.2 CH.sub.2SO.sub.3 K CH.sub.3 H      H C.sub.6 H.sub.4-p-OSO.sub.3 K 4 4-CH.sub.2 OC.sub.6       H.sub.5 H CONHCH.sub.3 7-CH.sub.2 OC.sub. 6 H.sub.5 CH.sub.3 C.sub.2      H.sub.5 C.sub.2 H.sub.5 CH.sub.2 OPh 4 4-CH.sub.2 OOCC.sub.6 H.sub.5 H      CH.sub.2 Ph 7-CH.sub.2 OOCC.sub.6 H.sub.5 H H H CH.sub.2 SO.sub.2 NHPh 4      5-CH.sub.2 COOCH.sub.3 H CH.sub.2 SO.sub.3 K 7-CH.sub.2 COOCH.sub.3      CH.sub.3 CH.sub.3 CH.sub.3 CH.sub.2 SO.sub.2 NHCH.sub.3 4 4-C.sub.6      H.sub.4-p-SO.sub.2 N(C.sub.2 H.sub.5).sub.2 H CH.sub.2 OSO.sub.3 K      7-C.sub.6 H.sub.4-p-SO.sub.2 N(C.sub.2 H.sub.5).sub.2 CH.sub.3 CH.sub.3      H C.sub.6 H.sub.4-p-SO.sub.2 NHCH.sub.3 4 4-CH.sub.2 CH.sub.2       NHCOOCH.sub.3 H C.sub.6 H.sub.4-p-SO.sub.3 K 7-CH.sub.2 CH.sub.2      NHCOOCH.sub.3 CH.sub.3 CH.sub.3 H CH.sub.2 COOCH.sub.3 3 4-CH.sub.2      NHCONHCH.sub.3 H CH.sub.2 CH.sub.2 OH 7-CH.sub.2 NHCONHCH.sub.3 CH.sub.3      CH.sub.3 H CH.sub.2 SO.sub.2       N(CH.sub.3).sub.2

                                      TABLE 6                                      __________________________________________________________________________      ##STR14##                                                                     Cinna-                                                                         moyl                                                                           Group                                                                          Posi-                  Substituents                                            tion                                                                               R.sub.1 on D  R.sub.5                                                                             on E    R.sub.1 on C  R.sub.3                                                                             R.sub.7                      __________________________________________________________________________     4   H             H    H       H             H    H                            4   4-NO.sub.2    H    COCH.sub.3                                                                             6-CH.sub.3    CH.sub.3                                                                            Ph                           4   4-CN          H    CH.sub.3                                                                               6-COCH.sub.3  C.sub.2 H.sub.5                                                                     C.sub.6 H.sub. 11            4   5-COCH.sub.3  H    Cl      6-OCH.sub.3   H    CH.sub.2CHCH.sub.2           4   4-COPh        CH.sub.3                                                                            CN      6-SO.sub.3 Na H    CH.sub.2 OOCC.sub.2                                                            H.sub.5                      4   2,4-di-COOH   CH.sub.3                                                                            CONH.sub.2                                                                             6-OCH.sub.2 CH.sub.2 SO.sub.4 K                                                              H    C.sub.6 H.sub.4                                                                -p-OOCCH.sub.3               4   4-OOCCH.sub.3 CH.sub.3                                                                            CH.sub.3                                                                               6-OCH.sub.2 CH.sub.2 SO.sub.4 K                                                              H    C.sub.6 H.sub.104-CH.sub                                                       .3                           4   4-NHCOCH.sub.3                                                                               CH.sub.3                                                                            CONHCH.sub.3                                                                           6-CH.sub.3    H    CH.sub.2 CH.sub.2                                                              (C.sub.4 H.sub.4                                                               O.sub.2 N)                   3   4-NHCOPh      CH.sub.3                                                                            OOCCH.sub.3                                                                            6-Ph          CH.sub.3                                                                            CH.sub.2 CH.sub.2                                                              NO.sub.2                     3   4-C.sub.2 H.sub.5                                                                            CH.sub.3                                                                            COOCH.sub.3                                                                            6-NO.sub.2    CH.sub.3                                                                            C.sub.6 H.sub.4p-NO.sub.                                                       2                            4   4-Ph          H    SCH.sub.3                                                                              6-OCH.sub.3   CH.sub.3                                                                            CH.sub.2 NHOCCH.sub.3        4   2,5-di-Cl     H    SCH.sub.2 CHCH.sub.2                                                                   6-NHCOCH.sub.3                                                                               C.sub.2 H.sub.5                                                                     CH.sub.2 NHSO.sub.2                                                            CH.sub.3                     4   2-Cl4-SO.sub.2 CH.sub.3                                                                      H    SPh     6-NHSO.sub.2 CH.sub.3                                                                        CH.sub.3                                                                            C.sub.6 H.sub.4                                                                -p-NHOCCH.sub.3              4   4-NHSO.sub.2 CH.sub.3                                                                        H    SC.sub.6 H.sub.11                                                                      6-COOCH.sub.3 CH.sub.3                                                                            C.sub.6 H.sub.4                                                                -p-NHSO.sub.2 CH.sub.3       4   4-COOCH.sub.3 H    OPh     6-COOH        H    C.sub.6 H.sub.104-NHOCCH                                                       .sub.3                       4   2-OCH.sub.3   C.sub.2 H.sub.5                                                                     OCH.sub.3                                                                              6-Cl          CH.sub.3                                                                            CH.sub.2 CH.sub.2 Cl         4   4-OC.sub.2 H.sub.5                                                                           C.sub.2 H.sub.5                                                                     Br      5,6-di-Br     C.sub.2 H.sub.5                                                                     C.sub.6 H.sub.4 -p-Br        4   4-SO.sub.3 Na C.sub.2 H.sub.5                                                                     CN      5,6-di-Br     H    C.sub.6 H.sub.4 -p-CN        4   2-SO.sub.3 Na C.sub.2 H.sub.5                                                                     H       5-OCH.sub.36-NHCOCH.sub.3                                                                    H    CH.sub.2 CH.sub.2 CN         4   2-OCH.sub.34-SO.sub.3 K                                                                      H    H       6-CH.sub.2 OOCCH.sub.3                                                                       H    CH.sub.2 CH.sub.2                                                              OC.sub.2 H.sub.5             4   4-OCH.sub.2 CH.sub.2 OSO.sub.3 K                                                             H    H       6-CH.sub.2 Cl H    CH.sub.2 CH.sub.2                                                              OCH.sub.2 CH.sub.2                                                             OC.sub.2 H.sub.5             4   2-SO.sub.3 Na5-Cl                                                                            H    COCH.sub.3                                                                             6-CN          H    CH.sub.2 Ph                  4   4-Cl          H    CH.sub.3                                                                               6-OOCCH.sub.3 CH.sub.3                                                                            CH.sub.2 C.sub.6                                                               H.sub.11                     4   4-OH          H    Cl      5-COOH        CH.sub.3                                                                            C.sub.6 H.sub.4 -o-OH        4   4-CH.sub.2 OOCCH.sub.3                                                                       C.sub.3 H.sub.7n                                                                    CN      5-OH          CH.sub.3                                                                            CH.sub.2 CH.sub.2 OH         4   4-SO.sub.3 K  C.sub.3 H.sub.7n                                                                    CONH.sub.2                                                                             5-CH.sub.2 CHCH.sub.2                                                                        C.sub.2 H.sub.5                                                                     CH.sub.2 CH.sub.2SO.sub.                                                       3 K                          4   4-OPh         H    CH.sub.3                                                                               6-CH.sub.3    CH.sub.3                                                                            C.sub.6 H.sub.4                                                                -p-OSO.sub.3 K               4   4-NO.sub.2    H    CONHCH.sub.3                                                                           6-COCH.sub.3  CH.sub.3                                                                            CH.sub.2 OPh                 4   5-CN          H    OOCCH.sub.3                                                                            6-OCH.sub.3   H    CH.sub.2 SO.sub.2 NHPh       4   4-COCH.sub.3  H    COOCH.sub.3                                                                            6-SO.sub.3 Na CH.sub.3                                                                            CH.sub.2 SO.sub.2                                                              NHCH.sub.3                   4   5-CH.sub.3    H    SCH.sub.3                                                                              6-OCH.sub.2 CH.sub.2 SO.sub.4 K                                                              H    C.sub.6 H.sub.4p-SO.sub.                                                       2 NHCH.sub.3                 4   5-Ph          H    SCH.sub.2 CHCH.sub.2                                                                   6-OCH.sub.2 CH.sub.2 SO.sub.3 K                                                              H    CH.sub.2 COOCH.sub.3         4   5-OCH.sub.3   H    SPh     6-CH.sub.3    H    CH.sub.2 SO.sub.2                                                              N(CH.sub.3).sub.2            4   4,5-di-Br     H    SC.sub.6 H.sub.11                                                                      6-Ph          H    C.sub.6 H.sub.4                                                                -p-NHCOOCH.sub.3             4   5-COOH        C.sub.4 H.sub.9n                                                                    OPh     6-NO.sub.2    C.sub.2 H.sub.5                                                                     CH.sub.2 CH.sub.2                                                              CONH.sub.2                   4   H             H    OCH.sub.3                                                                              6-OCH.sub.3   C.sub.2 H.sub.5                                                                     C.sub.6 H.sub.4                                                                -p-CONHCH.sub.3              4   4-NO.sub.2    H    Br      6-NHCOCH.sub.3                                                                               CH.sub.3                                                                            C.sub.6 H.sub.4                                                                -p-SCH.sub.3                 4   4-CN          H    CN      6-NHSO.sub.2 CH.sub.3                                                                        C.sub.3 H.sub.7n                                                                    CH.sub.2 CH.sub.2                                                              SCH.sub.3                    4   5-COCH.sub.3  H    H       6-COOCH.sub.3 H    CHC.sub.6 H.sub.4                                                              -p-SCH.sub.3                 4   4-COPh        CH.sub.3                                                                            H       6-COOH        CH.sub.3                                                                            CH.sub.2 SO.sub.2                                                              C.sub.2 H.sub.5              4   2,4-di-COH    CH.sub.3                                                                            H       8-Cl          H    CH.sub.2 SO.sub.2 Ph         4   4-OOCCH.sub.3 CH.sub.3                                                                            COCH.sub.3                                                                             5,6-di-Br     H    CH.sub.2 CH.sub.2                                                              OSO.sub.3 K                  4   4-NHCOCH.sub.3                                                                               CH.sub.3                                                                            CH.sub.3                                                                               5,6-di-Br     H    C.sub.6 H.sub.4                                                                -p-OSO.sub.3 K               4   4-NHCOPh      CH.sub.3                                                                            Cl      5-OCH.sub.36-NHCOCH.sub.3                                                                    H    CH.sub.2 (C.sub.8                                                              H.sub.4 O.sub.2 N)           4   4-CH.sub.2 CHCH.sub.2                                                                        H    CN      6-NHCOCH.sub.3                                                                               C.sub.2 H.sub.5                                                                     C.sub.2 H.sub.5              4   H             CH.sub.3                                                                            CONH.sub.2                                                                             6-OCPh        C.sub.2 H.sub.5                                                                     C.sub.2 H.sub.5              4   4-CONH.sub.2  H    CH.sub.3                                                                               6-CH.sub.2 CONHCH.sub.3                                                                      H    H                            4   3-SO.sub.2 NH.sub.2                                                                          H    CONHCH.sub.3                                                                           6-CH.sub.2 CON(CH.sub.3).sub.2                                                               CH.sub.3                                                                            Ph                           4   4-SO.sub.2 NHCH.sub.3                                                                        H    OOCCH.sub.3                                                                            6-CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2                                         OC.sub.2 H.sub.5                                                                             C.sub.2 H.sub.5                                                                     C.sub.6 H.sub.11             4   4-SO.sub.2 N(C.sub.2 H.sub.5).sub.2                                                          H    COOCH.sub.3                                                                            6-CH.sub.2 SC.sub.2 H.sub.5                                                                  H    CH.sub.2CHCH.sub.2           4   4-SO.sub.3 C.sub.6 H.sub.5                                                                   CH.sub.3                                                                            SCH.sub.3                                                                              6-CH.sub.2 SC.sub.6 H.sub.5                                                                  H    CH.sub.2 OOCC.sub.2                                                            H.sub.5                      4   4-SCH.sub.3   CH.sub.3                                                                            SCH.sub.2 CHCH.sub.2                                                                   6-CH.sub.2 SO.sub.2 C.sub.2 H.sub.5                                                          H    C.sub.6 H.sub.4                                                                -p-OOCCH.sub.3               4   2,4-di-SCN    CH.sub.3                                                                            SPh     6-CH.sub.2 SO.sub.2 C.sub.6 H.sub.5                                                          H    C.sub.6 H.sub.10                                                               -p-CH.sub.3                  4   4-SO.sub.2 C.sub.6 H.sub.5                                                                   CH.sub.3                                                                            SC.sub.6 H.sub.11                                                                      6-C.sub.6 H.sub.3 -o, -p-di-CN                                                               H    CH.sub.2 CH.sub.2(C.sub.                                                       4 H.sub.4 O.sub.2 N)         4   2-CHO4-CN     CH.sub.3                                                                            OPh     6-C.sub. 6 H.sub.2 -o, .sub.--m, -p-tri-Cl                                                   CH.sub.3                                                                            CH.sub.2 CH.sub.2                                                              NO.sub.2                     4   4-CONHC.sub.2 H.sub.5                                                                        CH.sub.3                                                                            OCH.sub.3                                                                              6,8-di-OSO.sub.3 NH(CH.sub.3).sub.3                                                          CH.sub.3                                                                            C.sub.6 H.sub.4                                                                -p-NO.sub.2                  4   4-CON(C.sub.2 H.sub.5).sub.2                                                                 H    Br      5,6-di-OSO.sub.3 Na                                                                          CH.sub.3                                                                            CH.sub.2 NHOCCH.sub.3        4   3-C.sub.6 H.sub.11                                                                           H    CN      5,6-di-OSO.sub. 3 Na                                                                         C.sub.2 H.sub.5                                                                     CH.sub.2 NHSO.sub.2                                                            CH.sub.3                     4   3-SC.sub.6 H.sub.5                                                                           H    H       5,6-di-SO.sub.3 NH(CH.sub.3).sub.3                                                           CH.sub.3                                                                            C.sub.6 H.sub.4                                                                -p-NHOCCH.sub.3              4   4-NHSO.sub.2 C.sub.6 H.sub.5                                                                 H    H       5,6-di-OSO.sub.3 Na                                                                          CH.sub.3                                                                            C.sub.6 H.sub.4                                                                -p-NHSO.sub.2 CH.sub.3       4   4-SC.sub.6 H.sub.11                                                                          H    H       6-SC.sub.6 H.sub.11                                                                          H    C.sub.6 H.sub.104-NHOCCH                                                       .sub.3                       4   4-C.sub.6 H.sub.4 -p-CH.sub.3                                                                C.sub.2 H.sub.5                                                                     COCH.sub.3                                                                             6-C.sub.6 H.sub.4 -p-CH.sub.3                                                                CH.sub.3                                                                            CH.sub.2 CH.sub.2 Cl         4   4-C.sub.6 H.sub.4 -p-CH.sub.2 CHCH.sub.2                                                     C.sub.2 H.sub.5                                                                     CH.sub.3                                                                               6-C.sub.6 H.sub.4 -p-CH.sub.2 CHCH.sub.2                                                     C.sub.2 H.sub.5                                                                     C.sub.6 H.sub.4 -p-Br        4   4-OCH.sub.2 CH.sub.2 NO.sub.2                                                                C.sub.2 H.sub.5                                                                     Cl      6-OCH.sub.2 CH.sub.2 NO.sub.2                                                                H    C.sub.6 H.sub.4 -p-CN        4   2-CH.sub.2 NHCOCH.sub.3                                                                      C.sub.2 H.sub.5                                                                     CN      6-CH.sub.2 NHCOCH.sub.3                                                                      H    CH.sub.2 CH.sub.2 CN         4   4-CH.sub.2 NHSO.sub.2 C.sub.2 H.sub.5                                                        H    CONH.sub.2                                                                             6-CH.sub.2 NHSO.sub.2 C.sub.2 H.sub.5                                                        H    CH.sub.2 CH.sub.2                                                              OC.sub.2 H.sub.5             4   4-CH.sub.2 CH.sub.2 Cl                                                                       H    CH.sub.3                                                                               6-CH.sub.2 CH.sub.2 Cl                                                                       H    CH.sub.2 CH.sub.2                                                              OCH.sub.2 CH.sub.2                                                             OC.sub.2 H.sub.5             4   2,6-di-CH.sub.2 CN                                                                           H    CONHCH.sub.3                                                                           5,6-di-CH.sub.2 CN                                                                           H    CH.sub.2 Ph                  4   4-CH.sub.2 CH.sub.2 OC.sub.2 H.sub.5                                                         H    OOCCH.sub.3                                                                            6-CH.sub.2 CH.sub.2 OC.sub.2 H.sub.5                                                         CH.sub.3                                                                            CH.sub.2 C.sub.6                                                               H.sub.11                     4   4-CH.sub.2 C.sub.6 H.sub.5                                                                   H    COOCH.sub.3                                                                            6-COOH        CH.sub.3                                                                            C.sub.6 H.sub.4 -o-OH        4   4-CH.sub.2 C.sub.6 H.sub.11                                                                  C.sub.3 H.sub.7n                                                                    SCH.sub.3                                                                              6-CH.sub.2 C.sub.6 H.sub.11                                                                  CH.sub.3                                                                            CH.sub.2 CH.sub.2 OH         4   4-CH.sub.2 CH(OH)CH.sub.2 OH                                                                 C.sub.3 H.sub.7n                                                                    SCH.sub.2 CHCH.sub.2                                                                   6-CH.sub.2 CH(OH)CH.sub.2 OH                                                                 C.sub.2 H.sub.5                                                                     CH.sub.2 CH.sub.2SO.sub.                                                       3 K                          4   4-CH.sub.2 CH.sub.2SO.sub.3 K                                                                H    SPh     6-CH.sub.2 CH.sub.2SO.sub.3 K                                                                CH.sub.3                                                                            C.sub.6 H.sub.4                                                                -p-OSO.sub.3 K               4   4-CH.sub.2 OC.sub.6 H.sub. 5                                                                 H    SC.sub.6 H.sub.11                                                                      6-CH.sub.2 OC.sub.6 H.sub.5                                                                  CH.sub.3                                                                            CH.sub.2 OPh                 4   4-CH.sub.2 OOCC.sub.6 H.sub.5                                                                H    OPh     6-CH.sub.2 OOCC.sub.6 H.sub.5                                                                H    CH.sub.2 SO.sub.2 NHPh       4   5-CH.sub.2 COOCH.sub.3                                                                       H    OCH.sub.3                                                                              5-CH.sub.2 COOCH.sub.3                                                                       CH.sub.3                                                                            CH.sub.2 SO.sub.2                                                              NHCH.sub.3                   4   4-C.sub.6 H.sub.4 -p-SO.sub.2 N(C.sub.2 H.sub.5).sub.2                                       H    Br      6-C.sub.6 H.sub.4 -p-SO.sub.2 N(C.sub.2                                        H.sub.5).sub.2                                                                               H    C.sub.6 H.sub.4                                                                -p-SO.sub.2 NHCH.sub.3       4   4-CH.sub.2 CH.sub.2 NHCOOCH.sub.3                                                            H    CN      6-CH.sub.2 CH.sub.2 NHCOOCH.sub.3                                                            H    CH.sub.2 COOCH.sub.3         4   4-CH.sub.2 NHCONHCH.sub.3                                                                    H    H       6-CH.sub.2 NHCONHCH.sub.3                                                                    H    CH.sub.2 SO.sub.2                                                              N(CH.sub.3).sub.2            4   4-CH.sub.2 CONH.sub.2                                                                        H    H       6-CH.sub.2 CONH.sub.2                                                                        H    C.sub.6 H.sub.4                                                                -p-NHCOOCH.sub.3             4   5-CH.sub.2 CONHCH.sub.3                                                                      C.sub.4 H.sub.9n                                                                    H       6-CONH.sub.2  C.sub.2 H.sub.5                                                                     CH.sub.2 CH.sub.2                                                              CONH.sub.2                   4   4-CH.sub.2 CON(CH.sub.3).sub.2                                                               H    COCH.sub.3                                                                             6-SO.sub.2 NH.sub.2                                                                          C.sub.2 H.sub.5                                                                     C.sub.6 H.sub.4                                                                -p-CONHCH.sub.3              4   4-CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2 OC.sub.2 H.sub.5                                      H    CH.sub.3                                                                               6-SO.sub.2 NHCH.sub.3                                                                        CH.sub.3                                                                            C.sub.6 H.sub.4                                                                -p-SCH.sub.3                 4   4-CH.sub.2 SC.sub.2 H.sub.5                                                                  H    Cl      6-SO.sub.2 N(C.sub.2 H.sub.5).sub.2                                                          C.sub.3 H.sub.7n                                                                    CH.sub.2 CH.sub.2                                                              SCH.sub.3                    4   5-CH.sub.2 SC.sub.6 H.sub.5                                                                  H    CN      6-SO.sub.3 C.sub.6 H.sub.5                                                                   H    CH.sub.2C.sub.6 H.sub.4                                                        -p-SCH.sub.3                 4   4-CH.sub.2 SO.sub.2 C.sub.2 H.sub.5                                                          CH.sub.3                                                                            CONH.sub.2                                                                             6-SCH.sub.3   CH.sub.3                                                                            CH.sub.2 SO.sub.2                                                              C.sub.2 H.sub.5              4   2,4-di-CH.sub.2 SO.sub.2 C.sub.6 H.sub.5                                                     CH.sub.3                                                                            CH.sub.3                                                                               5,6-di-SCN    H    CH.sub.2 SO.sub.2 Ph         4   4-C.sub.6 H.sub.3 -o, -p-di-CN                                                               CH.sub.3                                                                            CONHCH.sub.3                                                                           6-SO.sub.2 C.sub.6 H.sub.5                                                                   H    CH.sub.2 CH.sub.2                                                              OSO.sub.3 K                  4   4-C.sub.6 H.sub.2 -o, .sub.--m, -p-tri-Cl                                                    CH.sub.3                                                                            OOCCH.sub.3                                                                            5-CHO6-CN     H    C.sub.6 H.sub.4                                                                -p-OSO.sub.3 K               4   2,6-di-OSO.sub.3 Na                                                                          CH.sub.3                                                                            COOCH.sub.3                                                                            6-CONHC.sub.2 H.sub.5                                                                        H    CH.sub.2(C.sub.8                                                               H.sub.4 O.sub.2 N)           3   H             H    H       6-CON(C.sub.2 H.sub.5).sub.2                                                                 H    C.sub.2 H.sub.5              3   H             H    H       6-C.sub.6 H.sub.11                                                                           H    C.sub.2 H.sub.5              3   5-CH.sub.2 (C.sub.8 H.sub.4 O.sub.2 N)                                                       H    H       6-SC.sub.6 H.sub.5                                                                           H    C.sub.2 H.sub.5              4   5-CH.sub.2 (C.sub.4 H.sub.3 O)                                                               H    H       6-NHSO.sub.2 C.sub.6 H.sub.5                                                                 H    C.sub.2 H.sub.5              __________________________________________________________________________

    TABLE 7       ##STR15##        Cinnamoyl Group Position R.sub.1 on D R.sub.5 Substituents on G      R.sub.1 on C R.sub.2 R.sub.7        5 H H H H H H 5 4-NO.sub.2 H COCH.sub.3 2-CH.sub.3 C.sub.2 H.sub.5 Ph      5 4-CN H NO.sub.2 5-COCH.sub.3 C.sub.2 H.sub.5 C.sub.6 H.sub.11 5      5-COCH.sub.3 H Cl 5-OCH.sub.3 H CH.sub.2CHCH.sub.2 5 4-COPh CH.sub.3 CN      5-SO.sub.3 Na H CH.sub.2 OOCC.sub.2 H.sub.5 5 2,4-di-COOH CH.sub.3      NHSO.sub.2 CH.sub.3 5-OCH.sub.2 CH.sub.2 SO.sub.4 K H C.sub.6       H.sub.4-p-OOCCH.sub.3 5 4-OOCCH.sub.3 CH.sub.3 CH.sub.3 5-OCH.sub.2      CH.sub.2 SO.sub.4 NH(Et).sub.3 H C.sub.6       H.sub.104-CH.sub.3 4,5 4-NHCOCH.sub.3 CH.sub.3  2-CH.sub.3 H CH.sub.2      CH.sub.2 (C.sub.4 H.sub.4 O.sub.2 N) 5 4-NHCOPh CH.sub.3 Ph 2-Ph      CH.sub.3 CH.sub.2 CH.sub.2 NO.sub.2 5 4-C.sub.2 H.sub.5 CH.sub.3 H      2-NO.sub.2 CH.sub.3 C.sub.6 H.sub.4-p-NO.sub.2 5 4-Ph H H 2-OCH.sub.3      CH.sub.3 CH.sub.2 NHOCCH.sub.3 5 2-SO.sub.3 Na H CH.sub.3 H C.sub.2      H.sub.5 CH.sub.2 CH.sub.2 SO.sub.3 K 5 H H CH.sub.3 H C.sub.2 H.sub.5      C.sub.2 H.sub.5 4,5 2,5-di-Cl H  5-NHCOCH.sub.3 C.sub.2 H.sub.5 CH.sub.2      NHSO.sub.2 CH.sub.3 4 2-Cl4-SO.sub.2 CH.sub.3 H SO.sub.3 Na 3-NHSO.sub.2      CH.sub.3 C.sub.2 H.sub.5 C.sub.6 H.sub.4-p-NHOCCH.sub.3 4 4-NHSO.sub.2      CH.sub.3 H OCH.sub.2 CH.sub.2 SO.sub. 4 K 3-COOCH.sub.3 C.sub.2 H.sub.5      C.sub.6 H.sub.4-p-NHSO.sub.2 CH.sub.3 4 4-COOCH.sub.3 H OCH.sub.2      CH.sub.2 SO.sub.4 K 3-COOH C.sub.2 H.sub.5 C.sub.6       H.sub.104-NHOOCH.sub.3 4 2-OCH.sub.3 C.sub.2 H.sub.5 NHCOPh 2-Cl      CH.sub.2 CH.sub.2 Cl CH.sub.2 CH.sub.2 Cl 5 4-OC.sub.2 H.sub.5 C.sub.2      H.sub.5 NHCOPh 2,6-di-Br C.sub.6 H.sub.4-p-Br C.sub.6 H.sub.4-p-Br 5      4-SO.sub.3 Na C.sub.2 H.sub.5 NHCOCH.sub.3 2,6-di-Br C.sub.6       H.sub.4-p-CN C.sub.6 H.sub.4-p-CN 5 2-SO.sub.3 Na C.sub.2 H.sub.5      OOCC.sub.2 H.sub.5 2-OCH.sub.35-NHCOCH.sub.3 CH.sub.2 CH.sub.2 CN      CH.sub.2 CH.sub.2 CN 5 2-OCH.sub.34-SO.sub.3 K H COOH 2-CH.sub.2      OOCCH.sub.3 CH.sub.2 CH.sub.2 OC.sub.2 H.sub.5 CH.sub.2 CH.sub.2      OC.sub.2 H.sub.5 5 4-OCH.sub.2 CH.sub.2 OSO.sub.3 K H H 2-CH.sub.2 Cl      CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2 OC.sub.2 H.sub.5 CH.sub.2 CH.sub.2      OCH.sub.2 CH.sub.2 OC.sub.2 H.sub.5 5 2-SO.sub.3 Na5-Cl H H 2-CN      CH.sub.2 Ph CH.sub.2 Ph 5 4-Cl H SO.sub.2 CH.sub.3 2-OOCCH.sub.3      CH.sub.2 C.sub.6 H.sub.11 CH.sub.2 C.sub.6 H.sub.11 5 4-OH H CF.sub.3      5-COOH H C.sub.6 H.sub.4.sub.-o-OH 5 4-CH.sub.2 OOCCH.sub.3 C.sub.3      H.sub.7n COOCH.sub.3 5-OH C.sub.2 H.sub.5 CH.sub.2 CH.sub.2 OH 5      4-SO.sub.3 K C.sub.3 H.sub.7n CHO 5-CH.sub.2 CHCH.sub.2 CH.sub.2         S      CH.sub.2O.sub.3 K CH.sub.2 CH.sub.2SO.sub.3 K 5 4-OPh H CONH.sub.2      2-CH.sub.3 H C.sub.6 H.sub.4-p-OSO.sub.3 K 5 4-NO.sub.2 H CONCH.sub.3      5-COCH.sub.3 H CH.sub.2 OPh 5 5-CN H CH.sub.2 Ph 5-OCH.sub.3 H CH.sub.2      SO.sub.2 NHPh 5 4-COCH.sub.3 H CH.sub.2 SO.sub.3 K 5-SO.sub.3 Na      CH.sub.2 SO.sub.2 NHCH.sub.3 CH.sub.2 SO.sub.2 NHCH.sub.3 5 5-CH.sub.3 H      CH.sub.2 OSO.sub.3 K 5-OCH.sub.2 CH.sub.2 SO.sub.4 K H C.sub.6       H.sub.4-p-SO.sub.2 NHCH.sub.3 5 5-Ph H C.sub.6 H.sub.4-p-SO.sub.3 K      5-OCH.sub.2 CH.sub.2 SO.sub.3 K CH.sub.2 COOCH.sub.3 CH.sub. 2       COOCH.sub.3 5 5-OCH.sub.3 H CH.sub.3 CH.sub.2 OH 2-CH.sub.3 H CH.sub.2      SO.sub.2 N(CH.sub.3).sub.2 5 4,5-di-Br H CH.sub.2 Cl 2-Ph C.sub.2      H.sub.5 C.sub.6 H.sub.4-p-NHCOOCH.sub.3 5 5-COOH C.sub.4 H.sub.9n      C.sub.6 H.sub.4-p-Br 2-NO.sub.2 C.sub.2 H.sub.5 CH.sub.2 CH.sub.2      CONH.sub.2 5 H H H 2-OCH.sub.3 C.sub.2 H.sub.5 C.sub.6       H.sub.4-p-CONHCH.sub.3 5 4-NO.sub.2 H COCH.sub.3 5-NHCOCH.sub.3 C.sub.2      H.sub.5 C.sub.6 H.sub.4-p-SCH.sub.3 5 4-CN H NO.sub.2 3-NHSO.sub.2      CH.sub.3 CH.sub.2 CH.sub.2 SCH.sub.3 CH.sub.2 CH.sub.2 SCH.sub.3 5      5-COCH.sub.3 H Cl 3-COOCH.sub.3 H CH.sub.2C.sub.6 H.sub.4-p-SCH.sub.3 5      4-COPh CH.sub.3 CN 3-COOH CH.sub.2 SO.sub.2 C.sub.2 H.sub.5 CH.sub.2      SO.sub.2 C.sub.2 H.sub.5 5 2,4-di-COOH CH.sub.3 NHSO.sub.2 CH.sub.3 2-Cl      H CH.sub.2 SO.sub.2 Ph 5 4-OOCCH.sub.3 CH.sub.3 CH.sub.3 2,6-di-Br H      CH.sub.2 CH.sub.2 OSO.sub.3 K 5 4-NHCOCH.sub.3 CH.sub.3 OCH.sub.3      2,6-di-Br H C.sub.6 H.sub. 4-p-OSO.sub.3 K 5 4-NHCOPh CH.sub.3 Ph      2-OCH.sub.35-NHCOCH.sub.3 H CH.sub.2 (C.sub.8 H.sub.4 O.sub.2 N) 5      4-CH.sub.2 CHCH.sub.2 H H 3-NHCOCH.sub.3 C.sub.2 H.sub.5 C.sub.2 H.sub.5      5 H CH.sub.3 H 3-OCPh C.sub.2 H.sub.5 C.sub.2 H.sub.5 4 4-CONH.sub.2 H H      5-CH.sub.2 CONHCH.sub.3 H H 4 3-SO.sub.2       NH.sub.2 H COCH.sub.3 5-CH.sub.2 CON(CH.sub.3).sub.2 C.sub.2 H.sub.5 Ph      4 4-SO.sub.2 NHCH.sub.3 H NO.sub.2 5-CH.sub.2 CH.sub.2 OCH.sub.2      CH.sub.2 OC.sub.2 H.sub.5 C.sub.2 H.sub.4 C.sub.6 H.sub.11 4 4-SO.sub.2      N(C.sub.2 H.sub.5).sub.2 H Cl 5-CH.sub.2 SC.sub.2       H.sub.5 H CH.sub.2CHCH.sub.2 4 4-SO.sub.3 C.sub.6 H.sub.5 CH.sub.3 CN      2-CH.sub.2 SC.sub.6 H.sub.5 H CH.sub.2 OOCC.sub.2 H.sub.5 5 4-SCH.sub.3      CH.sub.3 NHSO.sub.2 CH.sub.3 5-CH.sub.2 SO.sub.2 C.sub.2 H.sub.5 H      C.sub.6 H.sub.4-p-OOCCH.sub.3 5 2,4-di-SCN CH.sub.3 CH.sub.3 5-CH.sub.2      SO.sub.2 C.sub.6 H.sub.5 H C.sub.6 H.sub.104-CH.sub.3 5 4-SO.sub.2      C.sub.6 H.sub.5 CH.sub.3 OCH.sub.3 5-C.sub.6 H.sub.3.sub.- -o,p-di-CN H      CH.sub.2 CH.sub.2 (C.sub.4 H.sub.4 O.sub.2 N) 5 2-CHO4-CN CH.sub.3 Ph      5-C.sub.6 H.sub.2.sub.- .sub.-- -o,m,p-tri-Cl CH.sub.3 CH.sub.2 CH.sub.2      NO.sub.2 5 4-CONHC.sub.2       H.sub.5 CH.sub.3 H 2,6-di-OSO.sub.3 NH(CH.sub.3).sub.3 CH.sub.3 C.sub.6      H.sub.4-p-NO.sub.2 5 4-CON(C.sub.2 H.sub.5).sub.2 H H 2,6-di-SO.sub.3      NH(CH.sub.3).sub.3 CH.sub.3 CH.sub.2 NHOCCH.sub.3 5 3-C.sub.6 H.sub.11 H      SO.sub.3 Na 2,6-di-OSO.sub.3 K C.sub.2 H.sub.5 CH.sub.2 NHSO.sub.2      CH.sub.3 5 3-SC.sub.6 H.sub.5 H SO.sub.3       Na 2-SO.sub.3 NH(CH.sub.3).sub.3 C.sub.2 H.sub.5 C.sub.6       H.sub.4-p-NHOCCH.sub.3 5 4-NHSO.sub.2 C.sub.6 H.sub.5 H OCH.sub.2      CH.sub.2 SO.sub.4 K 2-OSO.sub.3 NH(CH.sub.3).sub.3 C.sub.2 H.sub.5      C.sub.6 H.sub.4-p-NHSO.sub.2 CH.sub.3 5 4-SC.sub.6 H.sub.11 H OCH.sub.2      CH.sub.2 SO.sub.4 K 5-SC.sub.6 H.sub.11 C.sub.2 H.sub.5 C.sub. 6         4      H.sub.10-NHOCCH.sub.3 5 4-C.sub.6 H.sub.4-p-CH.sub.3 C.sub.2 H.sub.5      NHCOPh 5-C.sub.6 H.sub.4-p-CH.sub.3 CH.sub.2 CH.sub.2 Cl CH.sub.2      CH.sub.2 Cl 5 4-C.sub.6 H.sub.4-p-CH.sub.2 CHCH.sub.2 C.sub.2 H.sub.5      NHCOPh 5-C.sub.6 H.sub.4-p-CH.sub.2 CHCH.sub.2 C.sub.6 H.sub.4-p-Br      C.sub.6 H.sub.4-p-Br 5 4-OCH.sub.2 CH.sub.2 NO.sub.2 C.sub.2 H.sub.5      NHCOCH.sub.3 5-OCH.sub.2 CH.sub.2 NO.sub.2 C.sub.6 H.sub.4-p-CN C.sub.6      H.sub.4-p-CN 5 2-CH.sub.2 NHCOCH.sub.3 C.sub.2 H.sub.5 OOCC.sub.2      H.sub.5 2-CH.sub.2 NHCOCH.sub.3 CH.sub.2 CH.sub.2 CN CH.sub.2 CH.sub.2      CN 5 4-CH.sub.2 NHSO.sub.2 C.sub.2 H.sub.5 H COOH 5-CH.sub.2 NHSO.sub.2      C.sub.2 H.sub.5 CH.sub.2 CH.sub.2 OC.sub.2 H.sub.5 CH.sub.2 CH.sub.2      OC.sub.2 H.sub.5 5 4-CH.sub.2 CH.sub.2 Cl H H 5-CH.sub.2 CH.sub.2 Cl      CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2 OC.sub.2 H.sub.5 CH.sub.2 CH.sub.2      OCH.sub.2 CH.sub.2 OC.sub.2 H.sub.5 5 2,6-di-CH.sub.2       CN H H 2,6-di-CH.sub.2 CN CH.sub.2 Ph CH.sub.2 Ph 5 4-CH.sub.2 CH.sub.2      OC.sub.2 H.sub.5 H SO.sub.2 CH.sub.3 5-CH.sub.2 CH.sub.2 OC.sub.2      H.sub.5 CH.sub.2 C.sub.6 H.sub.11 CH.sub.2 C.sub.6 H.sub.11 5 4-CH.sub.2      C.sub.6 H.sub.5 H CH.sub.2 C.sub.6 H.sub.5 5-COOH H C.sub.6              o       H.sub.4.sub.--OH 5 4-CH.sub.2 C.sub.6 H.sub.11 C.sub.3 H.sub.7n      COOCH.sub.3 5-CH.sub.2 C.sub.6 H.sub.11 C.sub.2 H.sub.5 CH.sub.2      CH.sub.2 OH 5 4-CH.sub.2 CH(OH)CH.sub.2 OH C.sub.3       H.sub.7n CHO 5-CH.sub.2 CH(OH)CH.sub.2 OH CH.sub.2 CH.sub.2SO.sub.3 K      CH.sub.2 CH.sub.2SO.sub.3 K 5 4-CH.sub.2 CH.sub.2SO.sub.3 K H CONH.sub.2      5-CH.sub.2 CH.sub.2SO.sub.3 K H C.sub.6 H.sub.4-p-OSO.sub.3       K 5 4-CH.sub.2 OC.sub.6 H.sub.5 H CONHCH.sub.3 5-CH.sub.2 OC.sub.6      H.sub.5 H CH.sub.2 OPh 5 4-CH.sub.2 OOCC.sub.6 H.sub.5 H CH.sub.2 Ph      5-CH.sub.2 OOCC.sub.6 H.sub.5 H CH.sub.2 SO.sub.2 NHPh 5 5-CH.sub.2      COOCH.sub.3 H CH.sub.2 SO.sub.3 K 5-CH.sub.2 COOCH.sub.3 CH.sub.2      SO.sub.2 NHCH.sub.3 CH.sub.2 SO.sub.2 NHCH.sub.3 5 4-C.sub.6       H.sub.4-p-SO.sub.2 N(C.sub.2 H.sub.5).sub.2 H CH.sub.2 OSO.sub.3 K      5-C.sub.6 H.sub.4-p-SO.sub.2 N(C.sub.2 H.sub.5).sub.2 H C.sub.6       H.sub.4-p-SO.sub.2 NHCH.sub.3 5 4-CH.sub.2 CH.sub.2 NHCOOCH.sub.3 H      C.sub.6 H.sub.4-p-SO.sub.3 K 5-CH.sub.2 CH.sub.2 NHCOOCH.sub.3 CH.sub.2      COOCH.sub.3 CH.sub.2 COOCH.sub.3 5 4-CH.sub.2 NHCONHCH.sub.3 H CH.sub.2      CH.sub.2 OH 5-CH.sub.2 NHCONHCH.sub.3 H CH.sub.2 SO.sub.2       N(CH.sub.3).sub.2 5 4-CH.sub.2 CONH.sub.2 H CH.sub.2 Cl 5-CH.sub.2      CONH.sub.2 C.sub.2 H.sub.5 C.sub.6 H.sub.4-p-NHCOOCH.sub.3 5 5-CH.sub.2      CONHCH.sub.3 C.sub.4 H.sub.9n C.sub.6 H.sub.4-p-Br 5-CONH.sub.2 C.sub.2      H.sub.5 CH.sub.2 CH.sub.2 CONH.sub.2 5 4-CH.sub.2 CON(CH.sub.3).sub.2 H      H 3-SO.sub.2 NH.sub.2 C.sub.2 H.sub.5 C.sub.6 H.sub.4-p-CONHCH.sub.3 5      4-CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2 OC.sub.2 H.sub.5 H COCH.sub.3      5-SO.sub.2 NHCH.sub.2 C.sub.6 H.sub.5 C.sub.6 H.sub.4-p-SCH.sub.3 5      4-CH.sub.2 SC.sub.2 H.sub.5 H NO.sub.2 5-SO.sub.2 N(C.sub.2       H.sub.5).sub.2 CH.sub.2 CH.sub.2 SCH.sub.3 CH.sub.2 CH.sub.2 SCH.sub.3      5 5-CH.sub.2 SC.sub.6 H.sub.5 H Cl 5-SO.sub.3 C.sub.6       H.sub.5 H CH.sub.2C.sub.6 H.sub.4-p-SCH.sub.3 5 4-CH.sub.2 SO.sub.2      C.sub.2 H.sub.5 CH.sub.3 CN 5-SCH.sub.3 CH.sub.2 SO.sub.2 C.sub.2      H.sub.5 CH.sub.2 SO.sub.2 C.sub.2 H.sub.5 5 2,4-di-CH.sub.2 SO.sub.2      C.sub.6 H.sub.5 CH.sub.3 NHSO.sub.2 CH.sub.3 2,5-di-SCN H CH.sub.2      SO.sub.2 Ph 5 4-C.sub.6 H.sub.3.sub.--o,p-di-CN CH.sub.3 CH.sub.3      5-SO.sub.2 C.sub.6 H.sub.5 H CH.sub.2 OSO.sub.3 K 5 4-C.sub.6       H.sub.2.sub.-.sub.---o,m,p-tri-Cl CH.sub.3 OCH.sub.3 2-CHO6-CN H      C.sub.6 H.sub.4-p-OSO.sub.3 K 5 2,6-di-OSO.sub.3       Na CH.sub.3 Ph 5-CONHC.sub.2 H.sub.5 H CH.sub.2(C.sub.8 H.sub.4 O.sub.2      N) 5 H H CH.sub.2 (C.sub.4 H.sub.4 O.sub.2       N) 5-CON(C.sub.2 H.sub.5).sub.2 C.sub.2 H.sub.5 C.sub.2 H.sub.5 5 H H      CH.sub.2 (C.sub.4 H.sub.3 O) 3-C.sub.6 H.sub.11 C.sub.2 H.sub.5 C.sub.2      H.sub.5 5 5-CH.sub.2 (C.sub.8 H.sub.4 O.sub.2 N) H H 3-SC.sub.6 H.sub.5      C.sub.2 H.sub.5 C.sub.2 H.sub.5 5 5-CH.sub.2 (C.sub.4 H.sub.3 O) H H      6-NHSO.sub.2 C.sub.6 H.sub.5 C.sub.2 H.sub.5 C.sub.2       H.sub.5

    TABLE 8       ##STR16##        Cinnamoyl Group Position R.sub.1 on D R.sub.5 Substituents on G      R.sub.1 on C R.sub.3 R.sub.4 R.sub.8 R.sub.7        5 H H H H H H H H 5 4-NO.sub.2 H COCH.sub.3 7-CH.sub.3 CH.sub.3      CH.sub.3 CH.sub.3 Ph 5 4-CN H SCN 5-COCH.sub.3 CH.sub. 3 CH.sub.3 H      C.sub.6 H.sub.11 5 5-COCH.sub.3 H Cl 5-OCH.sub.3 CH.sub.3 CH.sub.3 H      CH.sub.2CHCH.sub.2 5 4-COPh CH.sub.3 CN 7-SO.sub.3 Na CH.sub.3 CH.sub.3      H CH.sub.2 OOCC.sub.2 H.sub.5 5 2,4-di-COOH CH.sub.3 H 7-OCH.sub.2      CH.sub.2 SO.sub.4 K CH.sub.3 CH.sub.3 H C.sub.6 H.sub.4-p-OOCCH.sub.3 5      4-OOCCH.sub.3 CH.sub.3 CH.sub.3 7-OCH.sub.2 CH.sub.2 SO.sub.4       NH(Et).sub.3 CH.sub.3 CH.sub.3 H C.sub.6       H.sub.104-CH.sub.3 5 4-NHCOCH.sub.3 CH.sub.3 SCH.sub.3 7-CH.sub.3      CH.sub.3 H H CH.sub.2 CH.sub.2 (C.sub.4 H.sub.4 O.sub.2 N) 5 4-NHCOPh      CH.sub.3 Ph 7-Ph CH.sub.3 H H CH.sub.2 CH.sub.2 NO.sub.2 5 4-C.sub.2      H.sub.5 CH.sub.3 H 7-NO.sub.2 CH.sub.3 H H C.sub.6 H.sub.4-p-NO.sub.2 5      4-Ph H H 7-OCH.sub.3 CH.sub.3 H H CH.sub.2 NHOCCH.sub.3 4 2,5-di-Cl H      SO.sub.2 Ph 7-NHCOCH.sub.3 CH.sub.3 H H CH.sub.2 NHSO.sub.2 CH.sub.3 4      2-Cl4-SO.sub.2 CH.sub.3 H COPh 7-NHSO.sub.2 CH.sub.3 CH.sub.3 H H      C.sub.6 H.sub.4-p-NHOCCH.sub.3 4 4-NHSO.sub.2 CH.sub.3 H H 7-COOCH.sub.3      CH.sub.3 C.sub.2 H.sub.5 C.sub.2 H.sub.5 C.sub. 6 H.sub.4-p-NHSO.sub.2      CH.sub.3 4 4-COOCH.sub.3 H H 7-COOH H H H C.sub.6 H.sub.104-NHOCCH.sub.3      4 2-OCH.sub.3 C.sub.2 H.sub.5 CON(C.sub.2 H.sub.5).sub.2 7-Cl CH.sub.3      CH.sub.3 CH.sub.3 CH.sub.2 CH.sub.2 Cl 4 4-OC.sub.2 H.sub.5 C.sub.2      H.sub.5 H 5,7-di-Br CH.sub.3 CH.sub.3 H C.sub.6       H.sub.4-p-Br 4 4-SO.sub.3 Na C.sub.2 H.sub.5 H 5,7-di-Br CH.sub.3      CH.sub.3 H C.sub.6 H.sub.4-p-CN 5 2-SO.sub.3 Na C.sub.2       H.sub.5 OOCC.sub.2 H.sub.5 5-OCH.sub.37-NHCOCH.sub.3 CH.sub.3 CH.sub.3      H CH.sub.2 CH.sub.2 CN 5 2-OCH.sub.34-SO.sub.3 K H C.sub.3 H.sub.7n      7-CH.sub.2 OOCCH.sub.3 CH.sub.3 CH.sub.3 H CH.sub.2 CH.sub.2 OC.sub.2      H.sub.5 5 4-OCH.sub. 2 CH.sub.2 OSO.sub.3 K H C.sub.2 H.sub.7 7-CH.sub.2      Cl CH.sub.3 CH.sub.3 H CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2 OC.sub.2      H.sub.5 5 2-SO.sub.3 Na5-Cl H Br 7-CN CH.sub.3 H H CH.sub.2 Ph 5 4-Cl H      SO.sub.2 CH.sub.3 7-OOCCH.sub.3 CH.sub.3 H H CH.sub.2 C.sub.6 H.sub.11 5      4-OH H Cl 5-COOH CH.sub.3 H H C.sub.6 H.sub.4-o-OH 5 4-CH.sub.2       OOCCH.sub.3 C.sub.3 H.sub.7n COOCH.sub.3 5-OH CH.sub.3 H H CH.sub.2      CH.sub.2 OH 5 4-SO.sub.3 K C.sub.3 H.sub.7n CHO 5-CH.sub.2 CHCH.sub.2      CH.sub.3 H H CH.sub.2 CH.sub.2SO.sub.3 K 5 4-OPh H CONH.sub.2 7-CH.sub.3      CH.sub.3 H H C.sub.6 H.sub.4-p-OSO.sub.3 K 5 4-NO.sub.2 H CONHCH.sub.3      7-COCH.sub.3 CH.sub.3 C.sub.2 H.sub.5 C.sub.2 H.sub.5 CH.sub.2 OPh 5      5-CN H Ph 7-OCH.sub.3 H H H CH.sub.2 SO.sub.2 NHPh 5 4-COCH.sub.3 H SCN      7-SO.sub.3 Na CH.sub.3 CH.sub.3 CH.sub.3 CH.sub.2 SO.sub.2 NHCH.sub.3 5      5-CH.sub.3 H CN 7-OCH.sub.2 CH.sub.2 SO.sub.4 K CH.sub.3 CH.sub.3 H      C.sub.6 H.sub.4-p-SO.sub.2 NHCH.sub.3 5 5-Ph H SO.sub.2 Ph 7-OCH.sub.2      CH.sub.2 SO.sub.3 K CH.sub.3 CH.sub.3 H CH.sub.2       COOCH.sub.3 5 5-OCH.sub.3 H CH.sub.3 7-CH.sub.3 CH.sub.3 CH.sub.3 H      CH.sub.2 SO.sub.2 N(CH.sub.3).sub.2 5 4,5-di-Br H Br 7-Ph CH.sub.3      CH.sub.3 H C.sub.6 H.sub.4-p-NHCOOCH.sub.3 5 5-COOH C.sub.4 H.sub.9n H      7-NO.sub.2 H H H CH.sub.2 CH.sub.2 CONH.sub.2 5 H H H 7-OCH.sub.3      CH.sub.3 CH.sub.3 CH.sub.3 C.sub.6 H.sub.4-p-CONHCH.sub.3 5 4-NO.sub.2 H      COCH.sub.3 7-NHCOCH.sub.3 CH.sub.3 CH.sub.3 H C.sub.6       H.sub.4-p-SCH.sub.3 5 4-CN H C.sub.4 H.sub.9n 7-NHSO.sub.2 CH.sub.3      CH.sub.3 CH.sub.3 H CH.sub.2 CH.sub.2 SCH.sub.3 5 5-COCH.sub.3 H Cl      7-COOCH.sub.3 CH.sub.3 CH.sub.3 H CH.sub. 2C.sub.6 H.sub.4-p-SCH.sub.3 5      4-COPh CH.sub.3 CH 7-COOH CH.sub.3 CH.sub.3 H CH.sub.2 SO.sub.2 C.sub.2      H.sub.5 5 2,4-di-COOH CH.sub.3 SO.sub.2 CH.sub.3 7-Cl CH.sub.3 CH.sub.3      H CH.sub.2 SO.sub.2 Ph 5 4-OOCCH.sub.3 CH.sub.3 CH.sub.3 5,7-di-Br      CH.sub.3 H H CH.sub.2 CH.sub.2 OSO.sub.3 K 5 4-NHCOCH.sub.3 CH.sub.3 CN      5,7-di-Br CH.sub.3 H H C.sub.6 H.sub.4-p-OSO.sub.3 K 5 4-NHCOPh CH.sub.3      Ph 5-OCH.sub.37-NHCOCH.sub.3 CH.sub.3 H H CH.sub.2 (C.sub.8 H.sub.4      O.sub.2 N) 5 4-CH.sub.2 CHCH.sub.2 H H 7-NHCOCH.sub.3 C.sub.2 H.sub.5 H      H C.sub.2 H.sub.5 5 H CH.sub.3 H 7-OCPh C.sub.2 H.sub.5 H H C.sub.2      H.sub.5 5 4-CONH.sub.2 H H 7-CH.sub.2 CONHCH.sub.3 H H H H 5 3-SO.sub.2      NH.sub.2 H COCH.sub.3 7-CH.sub.3 CON(CH.sub.3).sub.2 CH.sub.3 CH.sub.3      CH.sub.3 Ph 5 4-SO.sub.2 NHCH.sub.3 H H 7-CH.sub.2 CH.sub.2 OCH.sub.2      CH.sub.2 OC.sub.2 H.sub. 5 CH.sub.3 CH.sub.3 H C.sub.6 H.sub.11 5      4-SO.sub.2 N(C.sub.2 H.sub.5).sub.2 H Cl 7-CH.sub.2 SC.sub.2 H.sub.5      CH.sub.3 CH.sub.3 H CH.sub.2CHCH.sub.2 5 4-SO.sub.3 C.sub.6 H.sub.5      CH.sub.3 CN 7-CH.sub.2 SC.sub.6 H.sub.5 CH.sub.3 CH.sub.3 H CH.sub.2      OOCC.sub.2 H.sub.5 5 4-SCH.sub.3 CH.sub.3 SO.sub.2 CH.sub.3 7-CH.sub.2      SO.sub.2 C.sub.2 H.sub.5 CH.sub.3 CH.sub.3 H C.sub.6       H.sub.4-p-OOCCH.sub.3 5 2,4-di-SCN CH.sub.3 CH.sub.3 7-CH.sub.2      SO.sub.2 C.sub.6 H.sub.5 CH.sub.3 CH.sub.3 H C.sub.6 H.sub.104-CH.sub.3      5 4-SO.sub.2 C.sub.6 H.sub.5 CH.sub.3 CH.sub.3 7-C.sub.6       H.sub.3-o,-p-di-CN CH.sub.3 H H CH.sub.2 CH.sub.2(C.sub.4 H.sub.4      O.sub.2 N) 5 2-CHO4-CN CH.sub.3 Ph 7-C.sub.6       H.sub.2-o,.sub.--m,-p-tri-Cl CH.sub.3 H H CH.sub.2 CH.sub.2 NO.sub.2 5      4-CONHC.sub.2 H.sub.5 CH.sub. 3 H 5,7-di-OSO.sub.3 NH(CH.sub.3).sub.3      CH.sub.3 H H C.sub.6 H.sub.4-p-NO.sub.2 5 4-CON(C.sub.2 H.sub.5).sub.2 H      H 5,7-di-OSO.sub.3 Na CH.sub.3 H H CH.sub.2 NHOCCH.sub.3 5 3-C.sub.6      H.sub.11 H CN 5,7-di-SO.sub.3 NH(CH.sub.3).sub.3 CH.sub.3 H H CH.sub.2      NHSO.sub.2 CH.sub.3 5 3-SC.sub.6 H.sub.5 H C.sub.2 H.sub.5 7-OSO.sub.3      NH(CH.sub.3).sub.3 CH.sub.3 H H C.sub.6 H.sub.4-p-NHOCCH.sub.3 5      4-NHSO.sub.2 C.sub.6 H.sub.5 H H 5,7-di-OSO.sub.3 Na CH.sub.3 C.sub.2      H.sub.5 C.sub.2 H.sub.5 C.sub.6 H.sub.4-p-NHSO.sub.2       CH.sub.3 5 4-SC.sub.6 H.sub.11 H H 7-SC.sub.6 H.sub.11 H H H C.sub.6      H.sub.104-NHOCCH.sub.3 5 4-C.sub.6 H.sub.4-p-CH.sub.3 C.sub.2 H.sub.5 H      7-C.sub.6 H.sub.4-p-CH.sub.3 CH.sub.3 CH.sub.3 CH.sub.3 CH.sub.2      CH.sub.2 Cl 5 4-C.sub.6 H.sub.4-p-CH.sub.2 CHCH.sub.2 C.sub.2 H.sub.5 Cl      7-C.sub.6 H.sub.4-p-CH.sub.2 CHCH.sub.2 CH.sub.3 CH.sub.3 H C.sub.6      H.sub.4-p-Br 5 4-OCH.sub.2 CH.sub.2 NO.sub.2 C.sub.2       H.sub.5 H 7-OCH.sub.2 CH.sub.2 NO.sub.2 CH.sub.3 CH.sub.3 H C.sub.6      H.sub.4-p-CN 5 2-CH.sub.2 NHCOCH.sub.3 C.sub.2 H.sub.5 OOCC.sub.2      H.sub.5 7-CH.sub.2 NHCOCH.sub.3 CH.sub.3 CH.sub.3 H CH.sub.2 CH.sub.2 CN      5 4-CH.sub.2 NHSO.sub.2 C.sub.2 H.sub.5 H CH.sub.3 7-CH.sub.2 NHSO.sub.2      C.sub.2 H.sub.5 CH.sub.3 CH.sub.3 H CH.sub.2 CH.sub.2 OC.sub.2 H.sub.5 5      4-CH.sub.2 CH.sub.2 Cl H H 7-CH.sub.2 CH.sub.2 Cl CH.sub.3 CH.sub.3 H      CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2 OC.sub.2 H.sub.5 5 2,6-di-CH.sub.2      CN H H 5,7-di-CH.sub.2 CN CH.sub.3 H H CH.sub.2 Ph 5 4-CH.sub.2 CH.sub.2      OC.sub.2 H.sub.5 H SO.sub.2 CH.sub.3 7-CH.sub.2 CH.sub.2 OC.sub.2      H.sub.5 CH.sub.3 H H CH.sub.2 C.sub.6 H.sub.11 5 4-CH.sub.2 C.sub.6      H.sub.5 H Ph 7-COOH CH.sub.3 H H C.sub.6 H.sub.4-o-OH 5 4-CH.sub.2      C.sub.6 H.sub.11 C.sub.3 H.sub.7n COOCH.sub.3 7-CH.sub.2 C.sub.6      H.sub.11 CH.sub.3 H H CH.sub.2 CH.sub.2 OH 5 4-CH.sub.2 CH(OH)CH.sub.2      OH C.sub.3 H.sub.7n CHO 7-CH.sub.2 CH(OH)CH.sub.2 OH CH.sub.3 H H      CH.sub.2 CH.sub.2SO.sub.3 K 5 4-CH.sub.2 CH.sub.2SO.sub.3 K H CONH.sub.2      7-CH.sub.2 CH.sub.2SO.sub.3 K CH.sub.3 H H C.sub.6 H.sub.4-p-OSO.sub.3 K      5 4-CH.sub.2 OC.sub.6 H.sub.5 H CONHCH.sub.3 7-CH.sub.2 OC.sub.6 H.sub.5      CH.sub.3 C.sub.2 H.sub.5 C.sub.2 H.sub.5 CH.sub.2 OPh 5 4-CH.sub.2      OOCC.sub.6 H.sub.5 H SO.sub.2 C.sub.2 H.sub.5 7-CH.sub.2 OOCC.sub.6      H.sub.5 H H H CH.sub.2 SO.sub.2 NHPh 5 5-CH.sub.2 COOCH.sub.3 H SO.sub.2      CH.sub.3 7-CH.sub.2 COOCH.sub.3 CH.sub.3 CH.sub.3 CH.sub.3 CH.sub.2      SO.sub.2 NHCH.sub.3 5 4-C.sub. 6 H.sub.4-p-SO.sub.2 N(C.sub.2       H.sub.5).sub.2 H H 7-C.sub.6 H.sub.4-p-SO.sub.2 N(C.sub.2       H.sub.5).sub.2 CH.sub.3 CH.sub.3 H C.sub.6 H.sub.4-p-SO.sub.2       NHCH.sub.3 5 4-CH.sub.2 CH.sub.2 NHCOOCH.sub.3 H H 7-CH.sub.2 CH.sub.2      NHCOOCH.sub.3 CH.sub.3 CH.sub.3 H CH.sub.2 COOCH.sub.3 5 4-CH.sub.2      NHCONHCH.sub.3 H H 7-CH.sub.2 NHCONHCH.sub.3 CH.sub.3 CH.sub.3 H      CH.sub.2 SO.sub.2 N(CH.sub.3).sub.2 5 4-CH.sub.2 CONH.sub.2 H SC.sub.2      H.sub.5 7-CH.sub.2 CONH.sub.2 CH.sub.3 CH.sub.3 H C.sub.6       H.sub.4-p-NHCOOCH.sub.3 5 5-CH.sub.2 CONHCH.sub.3 C.sub.4 H.sub.9n      COC.sub.6 H.sub.5 7-CONH.sub.2 H H H CH.sub.2 CH.sub.2 CONH.sub.2 5      4-CH.sub.2 CON(CH.sub.3).sub.2 H H 7-SO.sub.2 NH.sub.2 CH.sub.3 CH.sub.3      CH.sub.3 C.sub.6 H.sub.4-p-CONHCH.sub.3 5 4-CH.sub.2 CH.sub.2 OCH.sub.2      CH.sub.2 OC.sub.2 H.sub.5 H COCH.sub.3 7-SO.sub.2 NHCH.sub. 3 CH.sub.3      CH.sub.3 H C.sub.6 H.sub.4-p-SCH.sub.3 5 4-CH.sub.2 SC.sub.2 H.sub.5 H      SCN 7-SO.sub.2 N(C.sub.2 H.sub.5).sub.2 CH.sub.3 CH.sub.3 H CH.sub.2      CH.sub.2 SCH.sub.3 5 5-CH.sub.2 SC.sub.6 H.sub.5 H Cl 7-SO.sub.3 C.sub.6      H.sub.5 CH.sub.3 CH.sub.3 H CH.sub.2C.sub.6 H.sub.4-p-SCH.sub.3 5      4-CH.sub.2 SO.sub.2 C.sub.2 H.sub.5 CH.sub.3 CN 7-SCH.sub.3 CH.sub.3      CH.sub.3 H CH.sub.2 SO.sub.2 C.sub.2 H.sub.5 5 2,4-di-CH.sub.2 SO.sub.2      C.sub.6 H.sub.5 CH.sub.3 Cl 5,7-di-SCN CH.sub.3 CH.sub.3 H CH.sub.2      SO.sub.2 Ph 5 4-C.sub.6 H.sub.3-o,-p-di-CN CH.sub.3 CH.sub.3 7-SO.sub.2      C.sub.6 H.sub.5 CH.sub.3 H H CH.sub.2 CH.sub.2 OSO.sub.3 K 5 4-C.sub.6      H.sub.2-o,.sub.--m,-p-tri-Cl CH.sub.3 CONH.sub.2 5-CHO7-CN CH.sub.3 H H      C.sub.6 H.sub.4-p-OSO.sub.3 K 5 2,6-di-OSO.sub.3       Na CH.sub.3 Ph 7-CONHC.sub.2 H.sub.5 CH.sub.3 H H CH.sub.2 (C.sub.8      H.sub.4 O.sub.2 N) 5 H H H 7-CON(C.sub.2 H.sub.5).sub.2 CH.sub.3 H H      C.sub.2 H 5 H H SO.sub.2 C.sub.6 H.sub.5 7-C.sub.6 H.sub.11 CH.sub.3 H H      C.sub.2 H.sub.5 5 5-CH.sub.2 (C.sub.8 H.sub.4 O.sub.2       N) H CHO 7-SC.sub.6 H.sub.5 CH.sub.3 H H C.sub.2 H.sub.5 5 5-CH.sub.2      (C.sub.4 H.sub.3 O) H Br 7-NHSO.sub.2 C.sub.6 H.sub.5 CH.sub.3 C.sub.2      H.sub.5 C.sub.2 H.sub.5 C.sub.2       H.sub.5

                                      TABLE 9                                      __________________________________________________________________________      ##STR17##                                                                     Cinna-                                                                         moyl                                                                           Group                                                                          Posi-                                                                          tion                                                                              R.sub.1 on D  R.sub.5                                                                             Substituents on G                                                                       R.sub.1 on C  R.sub.3                                                                             R.sub.7                      __________________________________________________________________________     5  H             H    H        H             H    H                            5  4-NO.sub.2    H    COCH.sub.3                                                                              6-CH.sub.3    C.sub.2 H.sub.5                                                                     Ph                           5  4-CN          H    NO.sub.2 6-COCH.sub.3  C.sub.2 H.sub.5                                                                     C.sub.6 H.sub.11             5  5-COCH.sub.3  H    Cl       6-OCH.sub.3   H    CH.sub.2CHCH.sub.2           5  4-COPh        CH.sub.3                                                                            CN       6-SO.sub.3 Na H    CH.sub.2 OOCC.sub.2                                                            H.sub.5                      5  2,4-di-COOH   CH.sub.3                                                                            NHSO.sub.2 CH.sub.3                                                                     6-OCH.sub.2 CH.sub.2 SO.sub.4 K                                                              H    C.sub.6 H.sub.4                                                                -p-OOCCH.sub.3               5  4-OOCCH.sub.3 CH.sub.3                                                                            CH.sub.3 6-OCH.sub.2 CH.sub.2 SO.sub.4 K                                                              H    C.sub.6 H.sub.104-CH.sub                                                       .3                           5  4-NHCOCH.sub.3                                                                               CH.sub.3                                                                            OCH.sub.3                                                                               6-CH.sub.3    H    CH.sub.2 CH.sub.2                                                              (C.sub.4 H.sub.4                                                               O.sub.2 N)                   5  4-NHCOPh      CH.sub.3                                                                            Ph       6-Ph          CH.sub.3                                                                            CH.sub.2 CH.sub.2                                                              NO.sub.2                     5  4-C.sub.2 H.sub.5                                                                            CH.sub.3                                                                            H        6-NO.sub.2    CH.sub.3                                                                            C.sub.6 H.sub.4                                                                -p-NO.sub.2                  5  4-Ph          H    H        6-OCH.sub.3   CH.sub.3                                                                            CH.sub.2 NHOCCH.sub.3        4  2,5-di-Cl     H    SO.sub.3 Na                                                                             6-NHCOCH.sub.3                                                                               C.sub.2 H.sub.5                                                                     CH.sub.2 NHSO.sub.2                                                            CH.sub.3                     4  2-Cl4-SO.sub.2 CH.sub.3                                                                      H    SO.sub.3 Na                                                                             6-NHSO.sub.2 CH.sub.3                                                                        CH.sub.3                                                                            C.sub.6 H.sub.4                                                                -p-NHOCCH.sub.3              4  4-NHSO.sub.2 CH.sub.3                                                                        H    OCH.sub.2 CH.sub.2 SO.sub.4 K                                                           6-COOCH.sub.3 CH.sub.3                                                                            C.sub.6 H.sub.4                                                                -p-NHSO.sub.2 CH.sub.3       4  4-COOCH.sub.3 H    OCH.sub.2 CH.sub.2 SO.sub.4 K                                                           6-COOH        H    C.sub.6 H.sub.104-NHOOCH                                                       .sub.3                       4  2-OCH.sub.3   C.sub.2 H.sub.5                                                                     NHCOPh   6-Cl          CH.sub.3                                                                            CH.sub.2 CH.sub.2 Cl         4  4-OC.sub.2 H.sub.5                                                                           C.sub.2 H.sub.5                                                                     NHCOPh   5,6-di-Br     C.sub.2 H.sub.5                                                                     C.sub.6 H.sub.4 -p-Br        4  4-SO.sub.3 Na C.sub.2 H.sub.5                                                                     NHCOCH.sub.3                                                                            5,6-di-Br     H    C.sub.6 H.sub.4 -p-CN        5  2-SO.sub.3 Na C.sub.2 H.sub.5                                                                     OOCC.sub.2 H.sub.5                                                                      5-OCH.sub.36-NHCOCH.sub.3                                                                    H    CH.sub.2 CH.sub.2 CN         5  2-OCH.sub.34-SO.sub.3 K                                                                      H    COOH     6-CH.sub.2 OOCCH.sub.3                                                                       H    CH.sub.2 CH.sub.2                                                              OC.sub.2 H.sub.5             5  4-OCH.sub.2 CH.sub.2 OSO.sub.3 K                                                             H    H        6-CH.sub.2 Cl H    CH.sub.2 CH.sub.2                                                              OCH.sub.2 CH.sub.2                                                             OC.sub.2 H.sub.5             5  2-SO.sub.3 Na5-Cl                                                                            H    H        2-CN          H    CH.sub.2 Ph                  5  4-Cl          H    SO.sub.2 CH.sub.3                                                                       6-OOCCH.sub.3 CH.sub.3                                                                            CH.sub.2 C.sub.6                                                               H.sub.11                     5  4-OH          H    CF.sub.3 5-COOH        CH.sub.3                                                                            C.sub.6 H.sub.4 -o-OH        5  4-CH.sub.2 OOCCH.sub.3                                                                       C.sub.3 H.sub.7n                                                                    COOCH.sub. 3                                                                            5-OH          CH.sub.3                                                                            CH.sub.2 CH.sub.2 OH         5  4-SO.sub.3 K  C.sub.3 H.sub.7n                                                                    CHO      5-CH.sub.2 CHCH.sub.2                                                                        C.sub.2 H.sub.5                                                                     CH.sub.2 CH.sub.2SO.sub.                                                       3 K                          5  4-OPh         H    CONH.sub.2                                                                              6-CH.sub.3    CH.sub.3                                                                            C.sub.6 H.sub.4                                                                -p-OSO.sub.3 K               5  4-NO.sub.2    H    CONHCH.sub.3                                                                            5-COCH.sub.3  CH.sub.3                                                                            CH.sub.2 OPh                 5  5-CN          H    CH.sub.2 Ph                                                                             6-OCH.sub.3   H    CH.sub.2 SO.sub.2 NHPh       5  4-COCH.sub.3  H    CH.sub.2 SO.sub.3 K                                                                     6-SO.sub.3 Na CH.sub.3                                                                            CH.sub.2 SO.sub.2                                                              NHCH.sub.3                   5  5-CH.sub.3    H    CH.sub.2 OSO.sub.3 K                                                                    6-OCH.sub.2 CH.sub.2 SO.sub.4 K                                                              H    C.sub.6 H.sub.4                                                                -p-SO.sub.2 NHCH.sub.3       5  5-Ph          H    C.sub.6 H.sub.4 -p-SO.sub.3 K                                                           6-OCH.sub.2 CH.sub.2 SO.sub.3 K                                                              H    CH.sub.2 COOCH.sub.3         5  5-OCH.sub.3   H    CH.sub.2 CH.sub.2 OH                                                                    6-CH.sub.3    H    CH.sub.2 SO.sub.2                                                              N(CH.sub.3).sub.2            5  4,5-di-Br     H    CH.sub.2 Cl                                                                             2-Ph          H    C.sub.6 H.sub.4                                                                -p-NHCOOCH.sub.3             5  5-COOH        C.sub.4 H.sub.9n                                                                    C.sub.6 H.sub. 4 -p-Br                                                                  6-NO.sub.2    C.sub.2 H.sub.5                                                                     CH.sub.2 CH.sub.2                                                              CONH.sub.2                   5  H             H    H        6-OCH.sub.3   C.sub.2 H.sub.5                                                                     C.sub.6 H.sub.4                                                                -p-CONHCH.sub.3              5  4-NO.sub.2    H    COCH.sub.3                                                                              6-NHCOCH.sub.3                                                                               CH.sub.3                                                                            C.sub.6 H.sub.4                                                                -p-SCH.sub.3                 5  4-CN          H    NO.sub.2 6-NHSO.sub.2 CH.sub.3                                                                        C.sub.3 H.sub.7n                                                                    CH.sub.2 CH.sub.2                                                              SCH.sub.3                    5  5-COCH.sub.3  H    Cl       6-COOCH.sub.3 H    CH.sub.2C.sub.6 H.sub.4                                                        -p-SCH.sub.3                 5  4-COPh        CH.sub.3                                                                            CN       6-COOH        CH.sub.3                                                                            CH.sub.2 SO.sub.2                                                              C.sub.2 H.sub.5              5  2,4-di-COOH   CH.sub.3                                                                            NHSO.sub.2 CH.sub.3                                                                     8-Cl          H    CH.sub.2 SO.sub.2 Ph         5  4-OOCCH.sub.3 CH.sub.3                                                                            CH.sub.3 5,6-di-Br     H    CH.sub.2 CH.sub.2                                                              OSO.sub.3 K                  5  4-NHCOCH.sub.3                                                                               CH.sub.3                                                                            OCH.sub.3                                                                               5,6-di-Br     H    C.sub.6 H.sub.4                                                                -p-OSO.sub.3 K               5  4-NHCOPh      CH.sub.3                                                                            Ph       2-OCH.sub.36-NHCOCH.sub.3                                                                    H    CH.sub.2 (C.sub.8                                                              H.sub.4 O.sub.2 N)           5  4-CH.sub.2 CHCH.sub.2                                                                        H    H        6-NHCOCH.sub.3                                                                               C.sub.2 H.sub.5                                                                     C.sub.2 H.sub.5              5  H             CH.sub.3                                                                            H        6-OCPh        C.sub.2 H.sub.5                                                                     C.sub.2 H.sub.5              5  4-CONH.sub.2  H    H        6-CH.sub.2 CONHCH.sub.3                                                                      H    H                            5  3-SO.sub.2 NH.sub.2                                                                          H    COCH.sub.3                                                                              6-CH.sub.2 CON(CH.sub.3).sub.2                                                               CH.sub.3                                                                            Ph                           5  4-SO.sub.2 NHCH.sub.3                                                                        H    NO.sub.2 6-CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2                                         OC.sub.2 H.sub.5                                                                             C.sub.2 H.sub.4                                                                     C.sub.6 H.sub.11             5  4-SO.sub.2 N(C.sub.2 H.sub.5).sub.2                                                          H    Cl       6-CH.sub.2 SC.sub.2 H.sub.5                                                                  H    CH.sub.2CHCH.sub.2           5  4-SO.sub.3 C.sub.6 H.sub.5                                                                   CH.sub.3                                                                            CN       6-CH.sub.2 SC.sub.6 H.sub.5                                                                  H    CH.sub.2 OOCC.sub.2                                                            H.sub.5                      5  4-SCH.sub.3   CH.sub.3                                                                            NHSO.sub.2 CH.sub.3                                                                     6-CH.sub.2 SO.sub.2 C.sub.2 H.sub.5                                                          H    C.sub.6 H.sub.4                                                                -p-OOCCH.sub.3               5  2,4-di-SCN    CH.sub.3                                                                            CH.sub.3 6-CH.sub.2 SO.sub.2 C.sub.6 H.sub.5                                                          H    C.sub.6 H.sub.104-CH.sub                                                       .3                           5  4-SO.sub.2 C.sub.6 H.sub.5                                                                   CH.sub.3                                                                            OCH.sub.3                                                                               6-C.sub.6 H.sub.3 -o, -p-di-CN                                                               H    CH.sub.2 CH.sub.2                                                              (C.sub.4 H.sub.4                                                               O.sub.2 N)                   5  2-CHO4-CN     CH.sub.3                                                                            Ph       6-C.sub.6 H.sub.2 -o, .sub.--m, -p-tri-Cl                                                    CH.sub.3                                                                            CH.sub.2 CH.sub.2                                                              NO.sub.2                     5  4-CONHC.sub.2 H.sub.5                                                                        CH.sub.3                                                                            H        6,8-di-OSO.sub.3 N H(CH.sub.3).sub.3                                                         CH.sub.3                                                                            C.sub.6 H.sub.4                                                                -p-NO.sub.2                  5  4-CON(C.sub.2 H.sub.5).sub.2                                                                 H    H        5,6-di-OSO.sub.3 Na                                                                          CH.sub.3                                                                            CH.sub.2 NHOCCH.sub.3        5  3-C.sub.6 H.sub.11                                                                           H    SO.sub.3 Na                                                                             5,6-di-OSO.sub.3 Na                                                                          C.sub.2 H.sub.5                                                                     CH.sub.2 NHSO.sub.2                                                            CH.sub.3                     5  3-SC.sub.6 H.sub.5                                                                           H    SO.sub.3 Na                                                                             5,6-di-SO.sub.3 N H(CH.sub.3).sub.3                                                          CH.sub.3                                                                            C.sub.6 H.sub.4                                                                -p-NHOCCH.sub.3              5  4-NHSO.sub.2 C.sub.6 H.sub.5                                                                 H    OCH.sub.2 CH.sub.2 SO.sub.4 K                                                           5,6-di-OSO.sub.3 Na                                                                          CH.sub.3                                                                            C.sub.6 H.sub.4                                                                -p-NHSO.sub.2 CH.sub.3       5  4-SC.sub.6 H.sub.11                                                                          H    OCH.sub.2 CH.sub.2 SO.sub.4 K                                                           6-SC.sub.6 H.sub.11                                                                          H    C.sub.6 H.sub.104-NHOCCH                                                       .sub.3                       5  4-C.sub.6 H.sub.4 -p-CH.sub.3                                                                C.sub.2 H.sub. 5                                                                    NHCOPh   6-C.sub.6 H.sub.4 -p-CH.sub.3                                                                CH.sub.3                                                                            CH.sub.2 CH.sub.2 Cl         5  4-C.sub.6 H.sub.4 -p-CH.sub.2 CHCH.sub.2                                                     C.sub.2 H.sub.5                                                                     NHCOPh   6-C.sub.6 H.sub.4 -p-CH.sub.2 CHCH.sub.2                                                     C.sub.2 H.sub.5                                                                     C.sub.6 H.sub.4 -p-Br        5  4-OCH.sub.2 CH.sub.2 NO.sub.2                                                                C.sub.2 H.sub.5                                                                     NHCOCH.sub.3                                                                            6-OCH.sub.2 CH.sub.2 NO.sub.2                                                                H    C.sub.6 H.sub.4 -p-CN        5  2-CH.sub.2 NHCOCH.sub.3                                                                      C.sub.2 H.sub.5                                                                     OOCC.sub.2 H.sub.5                                                                      6-CH.sub.2 NHCOCH.sub.3                                                                      H    CH.sub.2 CH.sub.2 CN         5  4-CH.sub.2 NHSO.sub.2 C.sub.2 H.sub.5                                                        H    COOH     6-CH.sub.2 NHSO.sub.2 C.sub.2 H.sub.5                                                        H    CH.sub.2 CH.sub.2                                                              OC.sub.2 H.sub.5             5  4-CH.sub.2 CH.sub.2 Cl                                                                       H    H        6-CH.sub.2 CH.sub.2 Cl                                                                       H    CH.sub.2 CH.sub.2                                                              OCH.sub.2 CH.sub.2                                                             OC.sub.2 H.sub.5             5  2,6-di-CH.sub.2 CN                                                                           H    H        5,6-di-CH.sub.2 CN                                                                           H    CH.sub.2 Ph                  5  4-CH.sub.2 CH.sub.2 OC.sub.2 H.sub.5                                                         H    SO.sub.2 CH.sub.3                                                                       6-CH.sub.2 CH.sub.2 OC.sub.2 H.sub.5                                                         CH.sub.3                                                                            CH.sub.2 C.sub.6                                                               H.sub.11                     5  4-CH.sub.2 C.sub.6 H.sub.5                                                                   H    CH.sub.2 C.sub.6 H.sub.5                                                                6-COOH        CH.sub.3                                                                            C.sub.6 H.sub.4o-OH          5  4-CH.sub.2 C.sub.6 H.sub.11                                                                  C.sub.3 H.sub.7n                                                                    COOCH.sub.3                                                                             6-CH.sub.2 C.sub.6 H.sub.11                                                                  CH.sub.3                                                                            CH.sub.2 CH.sub.2 OH         5  4-CH.sub.2 CH(OH)CH.sub.2 OH                                                                 C.sub.3 H.sub.7n                                                                    CHO      6-CH.sub.2 CH(OH)CH.sub.2 OH                                                                 C.sub.2 H.sub.5                                                                     CH.sub.2 CH.sub.2SO.sub.                                                       3 K                          5  4-CH.sub.2 CH.sub.2SO.sub.3 K                                                                H    CONH.sub.2                                                                              6-CH.sub.2 CH.sub.2SO.sub.3 K                                                                CH.sub.3                                                                            C.sub.6 H.sub.4                                                                -p-OSO.sub.3 K               5  4-CH.sub.2 OC.sub.6 H.sub.5                                                                  H    CONHCH.sub.3                                                                            6-CH.sub.2 OC.sub.6 H.sub.5                                                                  CH.sub.3                                                                            CH.sub.2 OPh                 5  4-CH.sub.2 OOCC.sub.6 H.sub.5                                                                H    CH.sub.2 Ph                                                                             6-CH.sub.2 OOCC.sub.6 H.sub.5                                                                H    CH.sub.2 SO.sub.2 NHPh       5  5-CH.sub.2 COOCH.sub.3                                                                       H    CH.sub.2 SO.sub.3 K                                                                     6-CH.sub.2 COOCH.sub.3                                                                       CH.sub.3                                                                            CH.sub.2 SO.sub.2                                                              NHCH.sub.3                   5  4-C.sub.6 H.sub.4 -p-SO.sub.2 N(C.sub.2 H.sub.5 ).sub.2                                      H    CH.sub.2 OSO.sub.3 K                                                                    6-C.sub.6 H.sub.4 -p-SO.sub.2 N(C.sub.2                                        H.sub.5).sub.2                                                                               H    C.sub.6 H.sub.4                                                                -p-SO.sub.2 NHCH.sub.3       5  4-CH.sub.2 CH.sub.2 NHCOOCH.sub.3                                                            H    C.sub.6 H.sub.4 -p-SO.sub.3 K                                                           6-CH.sub.2 CH.sub.2 NHCOOCH.sub.3                                                            H    CH.sub.2 COOCH.sub.3         5  4-CH.sub.2 NHCONHCH.sub.3                                                                    H    CH.sub.2 CH.sub.2 OH                                                                    6-CH.sub.2 NHCONHCH.sub.3                                                                    H    CH.sub.2 SO.sub.2                                                              N(CH.sub.3).sub.2            5  4-CH.sub.2 CONH.sub.2                                                                        H    CH.sub.2 Cl                                                                             6-CH.sub.2 CONH.sub.2                                                                        H    C.sub.6 H.sub.4                                                                -p-NHCOOCH.sub.3             5  5-CH.sub.2 CONHCH.sub.3                                                                      C.sub.4 H.sub.9n                                                                    C.sub.6 H.sub.4 -p-Br                                                                   6-CONH.sub.2  C.sub.2 H.sub.5                                                                     CH.sub.2 CH.sub.2                                                              CONH.sub.2                   5  4-CH.sub.2 CON(CH.sub.3).sub.2                                                               H    H        6-SO.sub.2 NH.sub.2                                                                          C.sub.2 H.sub.5                                                                     C.sub.6 H.sub.4                                                                -p-CONHCH.sub.3              5  4-CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2 OC.sub.2 H.sub.5                                      H    COCH.sub.3                                                                              6-SO.sub.2 NHCH.sub.2                                                                        CH.sub.3                                                                            C.sub.6 H.sub.4                                                                -p-SCH.sub.3                 5  4-CH.sub.2 SC.sub.2 H.sub.5                                                                  H    NO.sub.2 6-SO.sub.2 N(C.sub.2 H.sub.5).sub.2                                                          C.sub.3 H.sub.7n                                                                    CH.sub.2 CH.sub.2                                                              SCH.sub.3                    5  5-CH.sub.2 SC.sub.6 H.sub.5                                                                  H    Cl       6-SO.sub.3 C.sub.6 H.sub.5                                                                   H    CH.sub.2C.sub.6 H.sub.4                                                        -p-SCH.sub.3                 5  4-CH.sub.2 SO.sub.2 C.sub.2 H.sub.5                                                          CH.sub.3                                                                            CN       6-SCH.sub.3   CH.sub.3                                                                            CH.sub.2 SO.sub.2                                                              C.sub.2 H.sub.5              5  2,4-di-CH.sub.2 SO.sub.2 C.sub.6 H.sub.5                                                     CH.sub.3                                                                            NHSO.sub.2 CH.sub.3                                                                     5,6-di-SCN    H    CH.sub.2 SO.sub.2 Ph         5  4-C.sub.6 H.sub.3 -o, -p-di-CN                                                               CH.sub.3                                                                            CH.sub.3 6-SO.sub.2 C.sub.6 H.sub.5                                                                   H    CH.sub.2 CH.sub.2                                                              OSO.sub.3 K                  5  4-C.sub.6 H.sub.2 -o, .sub.--m, -p-tri-Cl                                                    CH.sub.3                                                                            OCH.sub.3                                                                               2-CHO6-CN     H    C.sub.6 H.sub.4                                                                -p-OSO.sub.3 K               5  2,6-di-OSO.sub.3 Na                                                                          CH.sub.3                                                                            Ph       5-CONHC.sub.2 H.sub.5                                                                        H    CH.sub.2(C.sub.8                                                               H.sub.4 O.sub.2 N)           5  H             H    CH.sub.2 (C.sub. 4 H.sub.4 O.sub.2 N)                                                   5-CON(C.sub.2 H.sub.5).sub.2                                                                 H    C.sub.2 H.sub.5              5  H             H    CH.sub.2 (C.sub.4 H.sub.3 O)                                                            6-C.sub.6 H.sub.11                                                                           H    C.sub.2 H.sub.5              5  5-CH.sub.2 (C.sub.8 H.sub.4 O.sub.2 N)                                                       H    H        6-SC.sub.6 H.sub.5                                                                           H    C.sub.2 H.sub.5              5  5-CH.sub.2 (C.sub.4 H.sub.3 O)                                                               H    H        6-NHSO.sub.2 C.sub.6 H.sub.5                                                                 H    C.sub.2 H.sub.5              __________________________________________________________________________

The invention has been described in detail with particular reference to preferred embodiments thereof, but it will be understood that variations and modifications can be effected within the spirit and scope of the invention. 

I claim:
 1. A dye having one of the structures ##STR18## wherein: A is a group of the structure ##STR19## rings E and G are unsubstituted or substituted in any position not occupied by a cinnamoyl group wherein the ring E substituent is selected from alkyl, halogen, cyano, carbamoyl, CONHalkyl, alkoxycarbonyl, alkanoyl, alkanoyloxy, alkylthio, alkenylthio, arylthio, cyclohexylthio, aryloxy, and alkoxy, and the ring G substituent is selected from alkyl, aryl, alkoxycarbonyl, alkanoyloxy, carbamoyl, CONHalkyl, CON(alkyl)₂, halogen, cyano, thiocyano, alkylthio, alkylsulfonyl, arylsulfonyl, formyl, alkanoyl, and aroyl; R₅ is H or alkyl; and each R₁ is a group selected from alkyl, aralkyl, alkenyl of 2-6 carbons, aryl, cyclohexyl, cyclohexylalkyl, alkoxy, halogen, hydroxy, alkylsulfonyl, cyano, carbamoyl, alkanoyl, alkanoyloxy, aroyl, alkoxycarbonyl, amino, sulfamoyl, alkylsulfamoyl, dialkylsulfamoyl, alkanoylamino, SO₃ C₆ H₅, alkylthio, thiocyano, arylsulfonyl, formyl, alkylcarbamoyl, dialkylcarbamoyl, NO₂, --SO₃ M, --OSO₃ M, --COOH, aryloxy, arylthio, alkylsulfonylamino, aroylamino, arylsulfonylamino, and cyclohexylthio, wherein the alkyl, alkylene, alkenyl, aryl, and cyclohexyl moieties of the above R₁ groups are unsubstituted or substituted with 1-3 substituents different from the parent moiety and independently selected from alkanoyloxy, alkyl, alkenyl, succinimido, --NO₂, alkanoylamino, alkylsulfonylamino, 1-(2-pyrrolidono), halogen, cyano, alkoxy, aryl, cyclohexyl, hydroxy, --SO₃ M, --OSO₃ M, aryloxy, furyl, aroyloxy, alkoxycarbonyl, --SO₂ N(alkyl)₂, NHCOOalkyl, NHCONHalkyl, glutarimido, phthalimido, CONH₂, CONHalkyl, CON(alkyl)₂, alkoxyalkoxy, alkylthio, arylthio, alkylsulfonyl, and arylsulfonyl, wherein M is selected from H⁺, NH₄ ⁺, Na⁺, K⁺, and the colorless cations of sulfuric acid or sulfonic acid salts of trimethylamine, triethylamine, tri(2-hydroxyethyl)amine, di(2-hydroxyethyl)amine, and N,N-dimethylaniline; and wherein the couplers C¹ have the formulae: ##STR20## wherein each R₁ is as defined above; R₂ and R₇ are each selected independently from hydrogen, alkyl, cyclohexylalkyl, alkenyl of 2-6 carbons, aryl, aralkyl and cyclohexyl, all of which groups including alkylene moieties are unsubstituted or substituted as defined above for the substituted R₁ groups; and R₃, R₄ and R₈ are each selected from hydrogen and alkyl.
 2. A dye according to claim 11 wherein: the substituents for rings E and G are selected from alkyl, alkylthio, halogen, cyano, alkoxycarbonyl, CONH₂, CONHalkyl, alkanoyl and alkanoyloxy; each R₁ on the cinnamoyl ring is selected from alkyl, aralkyl, aralkyl substituted with --SO₃ M or --SO₄ M, cyclohexylalkyl, cyclohexylalkyl substituted with --SO₃ M or --SO₄ M, alkoxy, or alkanoylamino; R₂ is H, alkyl, aralkyl, aralkyl substituted with --SO₃ M or --SO₄ M, cyclohexylalkyl, or cyclohexylalkyl substituted with --SO₃ M or --SO₄ M; R₇ is H, alkyl, aralkyl, aralkyl substituted with --SO₃ M or --SO₄ M, cyclohexylalkyl, cyclohexylalkyl substituted with --SO₃ M or --SO₄ M, sodio- or potassiosulfatoalkyl, sodio- or potassiosulfonicalkyl, or alkanoyloxyalkyl; each R₁ on the couplers is selected from aralkyl, aralkyl substituted with --SO₃ M or --SO₄ M, cyclohexylalkyl, --SO₃ Na, --SO₃ K, halogen, --SO₄ Na, --SO₄ K, alkyl, alkoxy, --COOH, --OH, or cyclohexylalkyl substituted with --SO₃ M or --SO₄ M; and R₅ is hydrogen.
 3. A dye according to claim 1 wherein: the cinnamoyl ring D is unsubstituted or substituted with halogen, COOH, OH, or SO₃ M; and wherein in an aniline coupler each substituent R₁ is a methyl, methoxy or acetamido group or a chlorine atom, each R₂ is hydrogen, a methyl or ethyl group or a sulfonated cyclohexyl or benzyl group and each R₇ is an ethyl or sulfonated ethyl group or an alkyl group of up to 4 carbon atoms substituted with a sulfonated phenyl group, each sulfonate group being of formula --SO₃ M, and wherein in a tetrahydroquinoline coupler R₁ and R₃ are methyl groups, each of R₄ and R₈ is hydrogen or a methyl group, and R₇ is an ethyl group or a group of formula CH₂ CH₂ OCOCH₃ or CH₂ CH₂ OSO₃ M.
 4. A dye according to claim 1 wherein the coupler C¹ has the formula ##STR21## wherein: each R₁ is as defined in claim 1; and R₂ and R₇ are each selected independently from hydrogen, alkyl, alkenyl of 2-6 carbons, aryl, and cyclohexyl, all of which groups including alkylene moieties are unsubstituted or substituted as defined in claim 1 for the substituted R₁ groups.
 5. A dye according to claim 1 wherein the coupler C¹ has the formula ##STR22## wherein: each R₁ is as defined in claim 1; R₇ is selected from hydrogen, alkyl, alkenyl of 2-6 carbons, aryl, and cyclohexyl, all of which groups including alkylene moieties are unsubstituted or substituted as defined in claim 1 for the substituted R₁ groups; and R₃, R₄ and R₈ are each selected from hydrogen and alkyl.
 6. A dye according to claim 1 wherein the coupler C¹ has the formula ##STR23## wherein: each R₁ is as defined in claim 1; R₇ is selected from hydrogen, alkyl, alkenyl of 2-6 carbons, aryl, and cyclohexyl, all of which groups including alkylene moieties are unsubstituted or substituted as defined in claim 1 for the substituted R₁ groups; and R₃ is selected from hydrogen and alkyl.
 7. The dye of claim 1 having the formula: ##STR24##
 8. The dye of claim 1 having the formula: ##STR25## 